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Study: Amino acid sequence of H5N8 hemagglutinin and neuraminidase has changed little from 1983 Ireland outbreak - risk of human infections is relatively low

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  • Study: Amino acid sequence of H5N8 hemagglutinin and neuraminidase has changed little from 1983 Ireland outbreak - risk of human infections is relatively low

    International Journal of Computer Theory and Engineering, Vol. 7, No. 2, April 2015
    Examining the Probability of the Critical Mutation of
    H5N8 by Comparing with H7N9 and H5N1 Using Apriori Algorithm and Support Vector Machine
    Dae Young Kim, Hye-Jun Kim, Junhyeok Bae, and Taeseon Yoon

    Abstract?In January, 2014, the outbreak of H5N8 in South
    Korea started in one duck farm. The representative outbreak of
    H5N8 is to turkey 1983 Ireland and to duck 2010 China.
    Obviously, people were concerned about whether this Influenza
    A virus is highly pathogenic or human transmissible. In this
    research to identify the probability of H5N8?s pathogenic rate,
    we will investigate its chance to have Cytokine Storm, a deadly
    attribute of Influenza A virus, by seeking similarity in
    glycoprotein amino acid sequence with H5N1, which has the
    same hemagglutinin subtype, using Support Vector Machine. In
    addition, to identify H5N8?s human transmissible possibility, we
    will compare the its year-on-year glycoprotein amino acid
    mutating trend with H7N9, which was previously known not to
    be transmissible to human but mutated to infect human, using
    Apriori Algorithm.
    Index Terms?Apriori algorithm, H5N8, H5N1, H7N9,
    influenza A Virus, support vector machine.
    A. Similarity between H5N8 and H5N1
    See the amino acid dataset of hemagglutinin and
    neuraminidase in H5N8 which was classified by SVM in the
    condition of window size 9, where the result is more precise
    compared to other window sizes (see Table III). It showed
    out that the accuracy of hemagglutinin was higher than
    neuraminidase. In other words, the classification of
    neuraminidase in H5N8 and H5N1 was better done than
    hemagglutinin and this means that the similarity of
    hemagglutinin in H5N8 and H5N1 is much higher. The high
    similarity of hemagglutinin in H5N1 and H5N8 can be
    explained by the same hemagglutinin subtype; H5. But since
    the similarity of neuraminidase is low, we cannot conclude
    that the H5N8 of 2010 and H5N1 are alike. Therefore, it is
    viewed that the H5N1?s feature of cytokine storm will not
    take place in H5N8 but this needs further prudent research to
    be confirmed.

    B. Comparison of the Mutational Attribution of H5N8 and
    H7N9 was not infectious to humans in 1988 to 2009. But,
    as the amino acid sequence of hemagglutinin and
    neuraminidase in H7N9 changed dramatically, it became
    infectious to humans starting from 2013. Especially, despite
    the same host, fowls, the sequence shows a great change.
    (See Fig. 3 ~ Fig. 8). As seen in the case of H7N9, the
    sufficient condition for the influenza to be infectious to
    human is to have a considerable change in the amino acid
    sequence even for the same host. However, compared to the
    mutation in H7N9, there was only a little change in the
    sequence between the 1983 H5N8 and 2010 H5N8
    . Thus, we
    concluded that the possibility of H5N8 to be infectious to
    humans is comparatively low.

    Ask Congress to Investigate COVID Origins and Government Response to Pandemic.

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