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Influenza Other Respir Viruses. 2014 Nov 1. doi: 10.1111/irv.12289. [Epub ahead of print]
A novel highly pathogenic H5N8 avian influenza virus isolated from a wild duck in China.
Fan S1, Zhou L, Wu D, Gao X, Pei E, Wang T, Gao Y, Xia X.
Author information
Abstract
Migrating wild birds are considered natural reservoirs of influenza viruses and serve as a potential source of novel influenza strains in humans and livestock. During routine avian influenza surveillance conducted in eastern China, a novel H5N8 (SH-9) reassortant influenza virus was isolated from a mallard duck in China. blast analysis revealed that the HA, NA, PB1, PA, NP, and M segments of SH-9 were most closely related to the corresponding segments of A/duck/Jiangsu/k1203/2010 (H5N8). The SH-9 virus preferentially recognized avian-like influenza virus receptors and was highly pathogenic in mice. Our results suggest that wild birds could acquire the H5N8 virus from breeding ducks and spread the virus via migratory bird flyways.
? 2014 The Authors. Influenza and Other Respiratory Viruses Published by John Wiley & Sons Ltd.
KEYWORDS:
H5N8; highly pathogenic avian influenza virus; wild duck
PMID:
25363159
[PubMed - as supplied by publisher]
A novel highly pathogenic H5N8 avian influenza virus isolated from a wild duck in China.
Fan S1, Zhou L, Wu D, Gao X, Pei E, Wang T, Gao Y, Xia X.
Author information
Abstract
Migrating wild birds are considered natural reservoirs of influenza viruses and serve as a potential source of novel influenza strains in humans and livestock. During routine avian influenza surveillance conducted in eastern China, a novel H5N8 (SH-9) reassortant influenza virus was isolated from a mallard duck in China. blast analysis revealed that the HA, NA, PB1, PA, NP, and M segments of SH-9 were most closely related to the corresponding segments of A/duck/Jiangsu/k1203/2010 (H5N8). The SH-9 virus preferentially recognized avian-like influenza virus receptors and was highly pathogenic in mice. Our results suggest that wild birds could acquire the H5N8 virus from breeding ducks and spread the virus via migratory bird flyways.
? 2014 The Authors. Influenza and Other Respiratory Viruses Published by John Wiley & Sons Ltd.
KEYWORDS:
H5N8; highly pathogenic avian influenza virus; wild duck
PMID:
25363159
[PubMed - as supplied by publisher]
