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Novel Reassortant Influenza A(H5N8) Viruses in Domestic Ducks, Eastern China
Haibo Wu, Xiaorong Peng, Lihua Xu, Changzhong Jin, Linfang Cheng, Xiangyun Lu, Tiansheng Xie, Hangping Yao, and Nanping WuComments to Author
Author affiliations: Zhejiang University, Hangzhou, China (H. Wu, X. Peng, C. Jin, L. Cheng, X. Lu, T. Xie, H. Yao, N. Wu); Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, Hangzhou (H. Wu, X. Peng, C. Jin, L. Cheng, X. Lu, T. Xie, H. Yao, N. Wu); Zhejiang Academy of Agricultural Science, Hangzhou (L. Xu)
Conclusions
We isolated 2 influenza A(H5N8) viruses were isolated from domestic ducks in eastern China in 2013. Results of phylogenetic analysis showed that these viruses were reassortant viruses that derived their genes from different virus subtypes. These reassortant H5N8 subtype viruses and their 3 possible parent viruses, A/duck/Jiangsu/k1203/2010 (H5N8), A/environment/Jiangxi/28/2009 (H11N9), and A/duck/Hunan/8?19/2009 (H4N2), were isolated in China. Both H5N8 subtype isolates were highly pathogenic for chickens and showed moderate pathogenicity for mice. Domestic ducks are considered the natural reservoir of avian influenza viruses and serve as reassortant hosts for creation of new virus subtypes. Continued circulation of these viruses may pose health threats for birds and humans.
Haibo Wu, Xiaorong Peng, Lihua Xu, Changzhong Jin, Linfang Cheng, Xiangyun Lu, Tiansheng Xie, Hangping Yao, and Nanping WuComments to Author
Author affiliations: Zhejiang University, Hangzhou, China (H. Wu, X. Peng, C. Jin, L. Cheng, X. Lu, T. Xie, H. Yao, N. Wu); Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, Hangzhou (H. Wu, X. Peng, C. Jin, L. Cheng, X. Lu, T. Xie, H. Yao, N. Wu); Zhejiang Academy of Agricultural Science, Hangzhou (L. Xu)
Conclusions
We isolated 2 influenza A(H5N8) viruses were isolated from domestic ducks in eastern China in 2013. Results of phylogenetic analysis showed that these viruses were reassortant viruses that derived their genes from different virus subtypes. These reassortant H5N8 subtype viruses and their 3 possible parent viruses, A/duck/Jiangsu/k1203/2010 (H5N8), A/environment/Jiangxi/28/2009 (H11N9), and A/duck/Hunan/8?19/2009 (H4N2), were isolated in China. Both H5N8 subtype isolates were highly pathogenic for chickens and showed moderate pathogenicity for mice. Domestic ducks are considered the natural reservoir of avian influenza viruses and serve as reassortant hosts for creation of new virus subtypes. Continued circulation of these viruses may pose health threats for birds and humans.
