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Biochem Genet
. 2024 Feb 13.
doi: 10.1007/s10528-024-10722-8. Online ahead of print. The Association Between Genetic Variants in ACE1and ACE2 Genes with Susceptibility to COVID-19 Infection
Hamid Abbaszadeh 1 , Hamid Kabiri-Rad 2 , Fariba Mohammadi 2 , Soheila Zangoie 3 , Mahdieh Rajabi-Moghaddam 4 , Shokouh Ghafari 5 , Masood Ziaee 6 , Davod Javanmard 6 , Ebrahim Miri-Moghaddam 7
Affiliations
Angiotensin-converting enzyme 2 (ACE2) receptors facilitate the entry of the causative virus severe acute respiratory syndrome coronavirus 2 (SARS‑CoV‑2) into target cells. Some ACE gene variants have been suggested to be involved in COVID-19 pathogenesis. So, the aim was to assess the association between ACE1 rs4646994 and ACE2 rs2285666 genes polymorphisms and the susceptibility and severity of COVID-19. This case-control study was conducted on 197 patients with COVID-19 and 197 healthy controls. ACE-1 insertion/deletion (I/D) (rs4646994) and ACE2 rs2285666 genes polymorphisms were determined by the amplification refractory mutation system- polymerase chain reaction (ARMS-PCR) technique. The DD genotype of ACE1 I/D polymorphism was associated with increased susceptibility to COVID-19 infection (p = 0.012), whereas the ID genotype of this polymorphism was associated with decreased susceptibility (p = 0.003) (significance level = 0.017). There was no significant association in allele and genotype distribution of ACE2 rs2285666 polymorphism between cases and controls. The ACE1 I/D polymorphism may be considered as a risk factor for COVID-19 susceptibility.
Keywords: Angiotensin-converting enzyme 2; COVID-19; Iran; Polymorphism; SARS-CoV-2.
. 2024 Feb 13.
doi: 10.1007/s10528-024-10722-8. Online ahead of print. The Association Between Genetic Variants in ACE1and ACE2 Genes with Susceptibility to COVID-19 Infection
Hamid Abbaszadeh 1 , Hamid Kabiri-Rad 2 , Fariba Mohammadi 2 , Soheila Zangoie 3 , Mahdieh Rajabi-Moghaddam 4 , Shokouh Ghafari 5 , Masood Ziaee 6 , Davod Javanmard 6 , Ebrahim Miri-Moghaddam 7
Affiliations
- PMID: 38349438
- DOI: 10.1007/s10528-024-10722-8
Angiotensin-converting enzyme 2 (ACE2) receptors facilitate the entry of the causative virus severe acute respiratory syndrome coronavirus 2 (SARS‑CoV‑2) into target cells. Some ACE gene variants have been suggested to be involved in COVID-19 pathogenesis. So, the aim was to assess the association between ACE1 rs4646994 and ACE2 rs2285666 genes polymorphisms and the susceptibility and severity of COVID-19. This case-control study was conducted on 197 patients with COVID-19 and 197 healthy controls. ACE-1 insertion/deletion (I/D) (rs4646994) and ACE2 rs2285666 genes polymorphisms were determined by the amplification refractory mutation system- polymerase chain reaction (ARMS-PCR) technique. The DD genotype of ACE1 I/D polymorphism was associated with increased susceptibility to COVID-19 infection (p = 0.012), whereas the ID genotype of this polymorphism was associated with decreased susceptibility (p = 0.003) (significance level = 0.017). There was no significant association in allele and genotype distribution of ACE2 rs2285666 polymorphism between cases and controls. The ACE1 I/D polymorphism may be considered as a risk factor for COVID-19 susceptibility.
Keywords: Angiotensin-converting enzyme 2; COVID-19; Iran; Polymorphism; SARS-CoV-2.