Arch Virol . Genomic evidence of SARS-CoV-2 reinfection cases in southern Brazil

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Arch Virol


. 2023 Jan 3;168(1):19.
doi: 10.1007/s00705-022-05648-8.
Genomic evidence of SARS-CoV-2 reinfection cases in southern Brazil


Ana Paula Muterle Varela ^{# 1} , Fernando Hayashi Sant'Anna ^{# 1} , Aniúsca Vieira Dos Santos ¹ , Janira Prichula ² , Juliana Comerlato ¹ , Giovana Tavares Dos Santos ¹ , Eliana Wendland ^{3 4}



Affiliations

• PMID: 36593369
• DOI: 10.1007/s00705-022-05648-8

Abstract

Cases of reinfection with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) have been reported worldwide. We investigated reinfection cases in a set of more than 30,000 samples, and the SARS-CoV-2 genomes from selected samples from four patients with at least two positive diagnoses with an interval ≥ 45 days between tests were sequenced and analyzed. Comparative genomic and phylogenetic analysis confirmed three reinfection cases and suggested that the fourth one was caused by a virus of the same lineage. Viral sequencing is crucial for understanding the natural course of reinfections and for planning public health strategies for management of COVID-19.