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Nature. Identifying SARS-CoV-2 related coronaviruses in Malayan pangolins

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  • Nature. Identifying SARS-CoV-2 related coronaviruses in Malayan pangolins


    Nature. 2020 Mar 26. doi: 10.1038/s41586-020-2169-0. [Epub ahead of print]
    Identifying SARS-CoV-2 related coronaviruses in Malayan pangolins.


    Lam TT1,2, Shum MH2, Zhu HC1,2, Tong YG3, Ni XB2, Liao YS2, Wei W4, Cheung WY2, Li WJ3, Li LF5, Leung GM2, Holmes EC6, Hu YL7,8, Guan Y9,10.

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    Abstract

    The ongoing outbreak of viral pneumonia in China and beyond is associated with a novel coronavirus, SARS-CoV-21. This outbreak has been tentatively associated with a seafood market in Wuhan, China, where the sale of wild animals may be the source of zoonotic infection2. Although bats are likely reservoir hosts for SARS-CoV-2, the identity of any intermediate host that might have facilitated transfer to humans is unknown. Here, we report the identification of SARS-CoV-2-related coronaviruses in Malayan pangolins (Manis javanica) seized in anti-smuggling operations in southern China. Metagenomic sequencing identified pangolin-associated coronaviruses that belong to two sub-lineages of SARS-CoV-2-related coronaviruses, including one that exhibits strong similarity to SARS-CoV-2 in the receptor-binding domain. The discovery of multiple lineages of pangolin coronavirus and their similarity to SARS-CoV-2 suggests that pangolins should be considered as possible hosts in the emergence of novel coronaviruses and should be removed from wet markets to prevent zoonotic transmission.



    PMID:32218527DOI:10.1038/s41586-020-2169-0


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