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Pediatr Pulmonol
. 2025 Jan;60(1):e27479.
doi: 10.1002/ppul.27479. Angiotensin-Converting Enzyme 2 (G8790A) Gene Polymorphism as a Risk Factor for COVID-19 in Egyptian Children and Adolescents
Ahmed A A Ibraheem 1 , Sarah A Saleh 2 , Ahmed A Emam 1 , Aly A Yousef 3 , Mohamed Abdulhay 3 , Mohammed K Haridi 4 , Ali A Wahba 5 , Marwa M Al-Fahham 6 , Dalia M Selim 6 , Suzan A Razek 6 , Ehab I Sorour 7 , El Sayed H F Abouzied 7 , Ahmed H Ismail 8 , Soma A Mohamed 9 , Attia A Soliman 1 , Hassan Shehata 1 , Faika Arab 1 , Marwa L M Rashad 1 , Sahbaa F M Hafez 1 , Khalil Abdelkhalek 2 , Dina M Ibrahim 2 , Bassem Ashraf 10 , Ahmed S E Saleh 11 , Rania A Fouad 12 13 , Walaa E Omar 13 , Rehab M Nabil 14 , Raghdaa A Ramadan 15 , Eman M El-Sehsah 16 , Mona R Afify 17 , Yasser Bawazir 18 , Mohammad Mustafa 19 , Yassir Daghistani 19 , Rawan A Thabit 20 , Wed Salah 21 , Laila M Almoraie 22 , Hanan Maas Aljamei 23 , Laila Ahmed Hummdi 23 , Emtenan Ali Arishi 24 , Hanan F Salem 25 , Yasmine M Massoud 26 , Dalia M Khalil 27 , Batoul M Abdel Raouf 6 , Hani A Elmikaty 28 , Sonya A A El-Gaaly 29 , Ahmed R Fakhreldin 30 , Mustafa I A Hashem 1
Affiliations
Objective: Recently, angiotensin-converting enzyme 2 (ACE2) gene has emerged as a potential candidate gene for susceptibility to SARS-CoV-2 infection. We investigated whether ACE2 G8790A (rs2285666) polymorphism could be a genetic marker for susceptibility to COVID-19 and disease severity in Egyptian children and adolescents.
Methods: This was a prospective case-control study included 580 cases diagnosed with COVID-19, and 580 matched control children and adolescents. The ACE2 G8790A (rs2285666) polymorphism was genotyped using polymerase chain reaction (PCR) and ACE2 serum level was measured by ELISA.
Results: The ACE2 A/A genotype and A-allele were significantly more represented in cases with COVID-19 as compared to control group (44% vs. 30%; OR = 2.83; [95% CI: 1.27-2.63]; p = 0.006; for the A/A genotype) and (65% vs. 51%; OR = 1.9; [95% CI: 1.06-1.72]; p = 0.01; for the A-allele). The presence of ACE2 G/G genotype was an independent risk factor for severe disease (adjusted OR: 2.08; [95% CI: 1.57-6.78]; p = 0.003).
Conclusion: The ACE2 G8790A (rs2285666) polymorphism may confer susceptibility to COVID-19 in Egyptian children and adolescents. The ACE2 G/G genotype and G-allele was associated with lower ACE2 serum levels and may constitute independent risk factors for disease severity.
Keywords: adolescents; angiotensin converting enzyme‐2; children; coronavirus disease 2019 (COVID‐19); gene polymorphism.
. 2025 Jan;60(1):e27479.
doi: 10.1002/ppul.27479. Angiotensin-Converting Enzyme 2 (G8790A) Gene Polymorphism as a Risk Factor for COVID-19 in Egyptian Children and Adolescents
Ahmed A A Ibraheem 1 , Sarah A Saleh 2 , Ahmed A Emam 1 , Aly A Yousef 3 , Mohamed Abdulhay 3 , Mohammed K Haridi 4 , Ali A Wahba 5 , Marwa M Al-Fahham 6 , Dalia M Selim 6 , Suzan A Razek 6 , Ehab I Sorour 7 , El Sayed H F Abouzied 7 , Ahmed H Ismail 8 , Soma A Mohamed 9 , Attia A Soliman 1 , Hassan Shehata 1 , Faika Arab 1 , Marwa L M Rashad 1 , Sahbaa F M Hafez 1 , Khalil Abdelkhalek 2 , Dina M Ibrahim 2 , Bassem Ashraf 10 , Ahmed S E Saleh 11 , Rania A Fouad 12 13 , Walaa E Omar 13 , Rehab M Nabil 14 , Raghdaa A Ramadan 15 , Eman M El-Sehsah 16 , Mona R Afify 17 , Yasser Bawazir 18 , Mohammad Mustafa 19 , Yassir Daghistani 19 , Rawan A Thabit 20 , Wed Salah 21 , Laila M Almoraie 22 , Hanan Maas Aljamei 23 , Laila Ahmed Hummdi 23 , Emtenan Ali Arishi 24 , Hanan F Salem 25 , Yasmine M Massoud 26 , Dalia M Khalil 27 , Batoul M Abdel Raouf 6 , Hani A Elmikaty 28 , Sonya A A El-Gaaly 29 , Ahmed R Fakhreldin 30 , Mustafa I A Hashem 1
Affiliations
- PMID: 39821718
- DOI: 10.1002/ppul.27479
Objective: Recently, angiotensin-converting enzyme 2 (ACE2) gene has emerged as a potential candidate gene for susceptibility to SARS-CoV-2 infection. We investigated whether ACE2 G8790A (rs2285666) polymorphism could be a genetic marker for susceptibility to COVID-19 and disease severity in Egyptian children and adolescents.
Methods: This was a prospective case-control study included 580 cases diagnosed with COVID-19, and 580 matched control children and adolescents. The ACE2 G8790A (rs2285666) polymorphism was genotyped using polymerase chain reaction (PCR) and ACE2 serum level was measured by ELISA.
Results: The ACE2 A/A genotype and A-allele were significantly more represented in cases with COVID-19 as compared to control group (44% vs. 30%; OR = 2.83; [95% CI: 1.27-2.63]; p = 0.006; for the A/A genotype) and (65% vs. 51%; OR = 1.9; [95% CI: 1.06-1.72]; p = 0.01; for the A-allele). The presence of ACE2 G/G genotype was an independent risk factor for severe disease (adjusted OR: 2.08; [95% CI: 1.57-6.78]; p = 0.003).
Conclusion: The ACE2 G8790A (rs2285666) polymorphism may confer susceptibility to COVID-19 in Egyptian children and adolescents. The ACE2 G/G genotype and G-allele was associated with lower ACE2 serum levels and may constitute independent risk factors for disease severity.
Keywords: adolescents; angiotensin converting enzyme‐2; children; coronavirus disease 2019 (COVID‐19); gene polymorphism.