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Cell Reports: Systems Vaccinology Identifies an Early Innate Immune Signature as a Correlate of Antibody Responses to the Ebola Vaccine rVSV-ZEBOV

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  • Cell Reports: Systems Vaccinology Identifies an Early Innate Immune Signature as a Correlate of Antibody Responses to the Ebola Vaccine rVSV-ZEBOV

    Systems Vaccinology Identifies an Early Innate Immune Signature as a Correlate of Antibody Responses to the Ebola Vaccine rVSV-ZEBOV

    Anne Rechtien8,9,Correspondence information about the author Anne RechtienEmail the author Anne Rechtien
    , Laura Richert8
    , Hadrien Lorenzo
    , Gloria Martrus
    , Boris Hejblum
    , Christine Dahlke
    , Rahel Kasonta
    , Madeleine Zinser
    , Hans Stubbe
    , Urte Matschl
    , Ansgar Lohse
    , Verena Krähling
    , Markus Eickmann
    , Stephan Becker
    , VEBCON Consortium
    , Rodolphe Thiébaut
    , Marcus Altfeld8
    , Marylyn Addo8,Correspondence information about the author Marylyn AddoEmail the author Marylyn Addo
    8These authors contributed equally
    9Lead Contact

    Highlights
    • • 5 early innate markers correlate with antibody response to Ebola vaccine rVSV-ZEBOV
    • • IP-10 on day 3 after vaccination is an independent correlate of antibody induction
    • • RNA-seq analysis identifies early gene expression signature linked to IP-10


    Summary

    Predicting vaccine efficacy remains a challenge. We used a systems vaccinology approach to identify early innate immune correlates of antibody induction in humans receiving the Ebola vaccine rVSV-ZEBOV. Blood samples from days 0, 1, 3, 7, and 14 were analyzed for changes in cytokine levels, innate immune cell subsets, and gene expression. Integrative statistical analyses with cross-validation identified a signature of 5 early innate markers correlating with antibody titers on day 28 and beyond. Among those, IP-10 on day 3 and MFI of CXCR6 on NK cells on day 1 were independent correlates. Consistently, we found an early gene expression signature linked to IP-10. This comprehensive characterization of early innate immune responses to the rVSV-ZEBOV vaccine in humans revealed immune signatures linked to IP-10. These results suggest correlates of vaccine-induced antibody induction and provide a rationale to explore strategies for augmenting the effectiveness of vaccines through manipulation of IP-10.


    full article

    http://www.cell.com/cell-reports/ful...showall%3Dtrue
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