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Reduced evolutionary rate in reemerged Ebola virus transmission chains

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  • Reduced evolutionary rate in reemerged Ebola virus transmission chains

    Reduced evolutionary rate in reemerged Ebola virus transmission chains
    • David J. Blackley1,*,
    • Michael R. Wiley2,*,
    • Jason T. Ladner2,*,
    • Mosoka Fallah3,*,
    • Terrence Lo1,
    • Merle L. Gilbert2,
    • Christopher Gregory1,
    • Jonathan D’ambrozio2,
    • Stewart Coulter1,
    • Suzanne Mate2,
    • Zephaniah Balogun1,
    • Jeffrey Kugelman2,
    • William Nwachukwu1,
    • Karla Prieto2,
    • Adolphus Yeiah3,
    • Fred Amegashie3,
    • Brian Kearney2,
    • Meagan Wisniewski2,
    • John Saindon1,
    • Gary Schroth4,
    • Lawrence Fakoli5,
    • Joseph W. Diclaro II6,
    • Jens H. Kuhn7,
    • Lisa E. Hensley7,
    • Peter B. Jahrling7,
    • Ute Str?her1,
    • Stuart T. Nichol1,
    • Moses Massaquoi3,
    • Francis Kateh3,
    • Peter Clement8,
    • Alex Gasasira8,
    • Fatorma Bolay5,
    • Stephan S. Monroe1,
    • Andrew Rambaut9,10,11,
    • Mariano Sanchez-Lockhart2,
    • A. Scott Laney1,
    • Tolbert Nyenswah3,,
    • Athalia Christie1, and
    • Gustavo Palacios2,
    + Author Affiliations
    • * These authors contributed equally to this work.



    Science Advances 29 Apr 2016:
    Vol. 2, no. 4, e1600378
    DOI: 10.1126/sciadv.1600378




    Using this rate of change as a signature, we identified two additional EVD clusters that possibly arose from persistently infected sources. These findings highlight the risk of EVD flare-ups even after an outbreak is declared over.


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