Reduced evolutionary rate in reemerged Ebola virus transmission chains
Science Advances 29 Apr 2016:
Vol. 2, no. 4, e1600378
DOI: 10.1126/sciadv.1600378
Using this rate of change as a signature, we identified two additional EVD clusters that possibly arose from persistently infected sources. These findings highlight the risk of EVD flare-ups even after an outbreak is declared over.
- David J. Blackley1,*,
- Michael R. Wiley2,*,
- Jason T. Ladner2,*,
- Mosoka Fallah3,*,
- Terrence Lo1,
- Merle L. Gilbert2,
- Christopher Gregory1,
- Jonathan Dambrozio2,
- Stewart Coulter1,
- Suzanne Mate2,
- Zephaniah Balogun1,
- Jeffrey Kugelman2,
- William Nwachukwu1,
- Karla Prieto2,
- Adolphus Yeiah3,
- Fred Amegashie3,
- Brian Kearney2,
- Meagan Wisniewski2,
- John Saindon1,
- Gary Schroth4,
- Lawrence Fakoli5,
- Joseph W. Diclaro II6,
- Jens H. Kuhn7,
- Lisa E. Hensley7,
- Peter B. Jahrling7,
- Ute Str?her1,
- Stuart T. Nichol1,
- Moses Massaquoi3,
- Francis Kateh3,
- Peter Clement8,
- Alex Gasasira8,
- Fatorma Bolay5,
- Stephan S. Monroe1,
- Andrew Rambaut9,10,11,
- Mariano Sanchez-Lockhart2,
- A. Scott Laney1,
- Tolbert Nyenswah3,,
- Athalia Christie1, and
- Gustavo Palacios2,
- ↵Corresponding author. Email: gustavo.f.palacios.ctr@mail.mil (G.P.); akc9@cdc.gov (A.C.); tgnyenswah74@yahoo.com(T.N.)
- ↵* These authors contributed equally to this work.
Science Advances 29 Apr 2016:
Vol. 2, no. 4, e1600378
DOI: 10.1126/sciadv.1600378
Using this rate of change as a signature, we identified two additional EVD clusters that possibly arose from persistently infected sources. These findings highlight the risk of EVD flare-ups even after an outbreak is declared over.