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Crystal Structure similarities between ebola virus, HIV and influenza virus

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  • Crystal Structure similarities between ebola virus, HIV and influenza virus

    http://www.cell.com/molecular-cell/a...2980159-8?cc=y
    Cell Volume 2, Issue 5, p605?616, November 1998
    Crystal Structure of the Ebola Virus Membrane Fusion Subunit, GP2, from the Envelope Glycoprotein Ectodomain
    Winfried Weissenhorn#,Andrea Carf?#,Kon-Ho Lee,John J. Skehel,Don C. Wiley
    DOI: http://dx.doi.org/10.1016/S1097-2765(00)80159-8
    Abstract

    We have determined the structure of GP2 from the Ebola virus membrane fusion glycoprotein by X-ray crystallography. The molecule contains a central triple-stranded coiled coil followed by a disulfide-bonded loop homologous to an immunosuppressive sequence in retroviral glycoproteins, which reverses the chain direction and connects to an α helix packed antiparallel to the core helices. The structure suggests that fusion peptides near the N termini form disulfide-bonded loops at one end of the molecule and that the C-terminal membrane anchors are at the same end. In this conformation, GP2 could both bridge two membranes and facilitate their apposition to initiate membrane fusion. We also find a heptad irregularity like that in low-pH-induced influenza HA2 and a solvent ion trapped in a coiled coil like that in retroviral TMs.
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