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Role of hematological parameters in the diagnosis of influenza virus infection in patients with respiratory tract infection symptoms

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  • Role of hematological parameters in the diagnosis of influenza virus infection in patients with respiratory tract infection symptoms


    J Clin Lab Anal. 2020 Jan 4:e23191. doi: 10.1002/jcla.23191. [Epub ahead of print] Role of hematological parameters in the diagnosis of influenza virus infection in patients with respiratory tract infection symptoms.

    Han Q1, Wen X2, Wang L1, Han X3, Shen Y1, Cao J1, Peng Q1, Xu J1, Zhao L1, He J1, Yuan H2.
    Author information

    1 Center of Clinical Laboratory, The First Affiliated Hospital of Soochow University, Suzhou, China. 2 Department of Clinical Laboratory, Shiqian People's Hospital, Tongren, China. 3 Department of Clinical Laboratory, Suzhou Dushuhu Public Hospital, Suzhou, China.

    Abstract

    BACKGROUND:

    The differential diagnoses of patients hospitalized for respiratory infections due to influenza virus vs other pathogens are challenging. Our study investigated whether hematological parameters such as neutrophil (N), lymphocyte (L), platelet (PLT), and neutrophil-to-lymphocyte ratio (NLR) contributed in diagnosing influenza virus infections and in discriminating other respiratory infections.
    METHODS:

    We retrospectively analyzed the laboratory characteristics of 307 patients with respiratory infections caused by influenza/non-influenza virus and bacteria. The diagnostic abilities of hematological indexes were evaluated in the patients compared with 100 healthy people.
    RESULTS:

    The hematological parameters in patients with influenza virus infection were dramatically altered compared with those in the controls. Additionally, among the systemic inflammatory markers, the sensitivity of NLR for influenza detection was higher than that of N and L. PLT was significantly lower in influenza virus-positive infection than in influenza virus-negative infection. Moreover, when patients with influenza virus infection were cured, PLT returned to a normal level. The red blood cell (RBC) and hemoglobin (Hb) levels of influenza virus infection were higher than those of bacterial infection. Compared with traditional N and L, NLR and platelet-to-neutrophil (PNR) showed greater significance between influenza virus and bacterial infection (P < .01).
    CONCLUSION:

    Neutrophil-to-lymphocyte ratio with high sensitivity is a preferable diagnostic tool to screen influenza virus-infected patients than N and L. PLT accounts in the differential diagnoses of respiratory infections due to influenza virus and other pathogens among patients. In addition, RBC, Hb, NLR, and PNR can significantly differentiate between influenza virus infections and bacterial infections.
    ? 2020 The Authors. Journal of Clinical Laboratory Analysis Published by Wiley Periodicals, Inc.


    KEYWORDS:

    hematological parameters; influenza virus infection; neutrophil-to-lymphocyte ratio; platelet; respiratory tract infection

    PMID: 31901184 DOI: 10.1002/jcla.23191

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