Fluorescent sialic derivatives for the specific detection of influenza viruses

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Bioorg Med Chem Lett. 2019 Oct 31:126773. doi: 10.1016/j.bmcl.2019.126773. [Epub ahead of print] Fluorescent sialic derivatives for the specific detection of influenza viruses.

Liu D¹, Cui X¹, Dhawane AN¹, Chivukula V², Iyer SS³.
Author information

1 788 Petit Science Center, Department of Chemistry, Centre for Diagnostics and Therapeutics, Georgia State University, Atlanta, GA 30302, United States. 2 Atlanta Metropolitan State College, 1630 Metropolitan Parkway, Atlanta, GA 30310, United States. 3 788 Petit Science Center, Department of Chemistry, Centre for Diagnostics and Therapeutics, Georgia State University, Atlanta, GA 30302, United States. Electronic address: siyer@gsu.edu.

Abstract

Early and accurate diagnosis of influenza viruses can decrease its harmful impact. Here, we have synthesized fluorescent sialic acid derivatives that are cleaved by influenza neuraminidases (NAs) and not by Streptococcus pneumoniae that also inhabits the human olfactory. We have also attempted to develop assays that could differentiate between influenza virus and S. pneumoniae by taking advantage of the structural differences between NAs from these pathogens.
Copyright ? 2019 Elsevier Ltd. All rights reserved.


KEYWORDS:

Glycan; Influenza; Neuraminidase; Sialic acid; Streptococcus pneumoniae

PMID: 31718863 DOI: 10.1016/j.bmcl.2019.126773