J Clin Lab Anal. 2019 Aug 16:e22995. doi: 10.1002/jcla.22995. [Epub ahead of print]
The application of lymphocyte*platelet and mean platelet volume/platelet ratio in influenza A infection in children.

Fei Y1, Zhang H1, Zhang C1.
Author information

1 Department of Clinical Laboratory, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.



To explore the characteristics and regularity of complete blood count (CBC) changes among influenza A-positive child patients and to discover parameters that can help with the diagnosis and differential diagnosis.

One hundred and ninety-one influenza A-positive children, two hundred and nineteen influenza A-negative children with influenza-like symptoms, and two hundred and forty-seven healthy children were included in this study. They were divided into three groups: influenza A-positive patient group, influenza A-negative patient group, and control group. Reverse transcriptase polymerase chain reaction testing and Sysmex XS-800i hematology analyzer were used to obtain influenza A and CBC results, respectively. CBC along with parameters including lymphocyte-to-monocyte ratio (LMR), neutrophil-to-lymphocyte ratio (NLR), platelet-to-lymphocyte ratio (PLR), mean platelet volume/platelet ratio (MPV/PLT), and lymphocyte*platelet (LYM*PLT) was calculated and recorded for each child. The differences in these parameters among different groups were tested with SPSS 15.0. The diagnostic values were also evaluated.

The LYM and PLT of child patients with influenza A were significantly lower than those of both influenza A-negative patients with influenza-like symptoms and healthy controls. Among all the parameters, LYM*PLT has the largest area under the curve and the highest diagnostic value, followed by MPV/PLT. Compared with using LMR or MPV/PLT, the diagnostic value of using LYM alone was, on the contrary, higher.

Low LYM*PLT and high MPV/PLT may indicate influenza A infection in children with influenza-like symptoms, which can be a useful indicator for diagnosis and differentiation of influenza A infection.
2019 The Authors. Journal of Clinical Laboratory Analysis published by Wiley Periodicals, Inc.


influenza A; lymphopenia; mean platelet volume; thrombocytopenia

PMID: 31420904 DOI: 10.1002/jcla.22995