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Evaluation of FilmArray respiratory panel multiplex polymerase chain reaction assay for detection of pathogens in adult outpatients with acute respiratory tract infection

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  • Evaluation of FilmArray respiratory panel multiplex polymerase chain reaction assay for detection of pathogens in adult outpatients with acute respiratory tract infection

    J Infect Chemother. 2018 Jun 9. pii: S1341-321X(18)30151-X. doi: 10.1016/j.jiac.2018.05.006. [Epub ahead of print]
    Evaluation of FilmArray respiratory panel multiplex polymerase chain reaction assay for detection of pathogens in adult outpatients with acute respiratory tract infection.

    Kaku N1, Hashiguchi K2, Iwanaga Y3, Akamatsu N3, Matsuda J3, Kosai K3, Uno N3, Morinaga Y3, Kitazaki T2, Hasegawa H3, Miyazaki T4, Fukuda M2, Izumikawa K5, Mukae H4, Yanagihara K3.
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    Abstract

    Although viruses are the major pathogen that causes upper respiratory tract infection (URTI) and acute bronchitis, antibiotics have been prescribed. This was a prospective observational study in influenza epidemics that enrolled adult outpatients who visited a hospital with respiratory tract infection symptoms. In this study, we evaluated the usefulness of FilmArray respiratory panel (RP). Fifty patients were enrolled. FilmArray RP detected the pathogens in 28 patients. The common pathogens were influenza virus (n = 14), respiratory syncytial virus (n = 6), and human rhinovirus (n = 6). Of the 14 patients with influenza virus, 6 were negative for the antigen test. The physicians diagnosed and treated the patients without the result of FilmArray in this study. Of the patients with positive FilmArray RP, 9 were treated with antibiotics; however, bacteria were detected in only 3 patients. By implementing FilmArray RP, URTI and acute bronchitis would be precisely diagnosed, and inappropriate use of antibiotics can be reduced.


    KEYWORDS:

    Influenza; Molecular biology; Respiratory infection; Viral infection

    PMID: 29895452 DOI: 10.1016/j.jiac.2018.05.006
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