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Evaluation of a two-stage testing algorithm for the diagnosis of respiratory viral infections

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  • Evaluation of a two-stage testing algorithm for the diagnosis of respiratory viral infections

    Diagn Microbiol Infect Dis. 2018 Mar 12. pii: S0732-8893(18)30085-3. doi: 10.1016/j.diagmicrobio.2018.03.007. [Epub ahead of print]
    Evaluation of a two-stage testing algorithm for the diagnosis of respiratory viral infections.

    Gardiner BJ1, Parker CEV2, Rabson AR3, Snydman DR4, Doron S4.
    Author information

    Abstract

    New on-demand multiplex molecular respiratory viral diagnostics offer superior performance although can be expensive and some platforms cannot process multiple specimens simultaneously. We performed a retrospective study reviewing results of patients tested for respiratory viruses following introduction of a two-stage testing algorithm incorporating an initial screen with Sofia® immunoassay then secondary Biofire Filmarray®, and compared to a period when only Filmarray® was used. Of 2976 testing episodes, 1814 underwent initial Sofia® then follow-up FilmArray®. A diagnosis of influenza was made by Sofia® in 282 patients, and by FilmArray® in an additional 163 (median time to result 1.12hours versus 3.46hours, P<0.001). Significantly more patients received their diagnosis within 90minutes in winter despite testing more samples (11.1% versus 3.4%, P<0.001), and approximately $36,000 was saved. An algorithmic approach to respiratory viral diagnosis can combine the advantages of accuracy and speed and be cost saving.


    KEYWORDS:

    Diagnosis; Influenza; PCR; Respiratory viral infection

    PMID: 29636246 DOI: 10.1016/j.diagmicrobio.2018.03.007
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