Adv Exp Med Biol. 2017 Mar 18. doi: 10.1007/5584_2016_181. [Epub ahead of print]
Rapid Influenza Diagnostic Tests Improve Suitability of Antiviral Treatment in Hospitalized Children.

Nitsch-Osuch A1, Kuchar E2, Gołębiak I3, Kanecki K3, Tarka P3, Brydak L4.
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Influenza may have a complicated course in young children. The aim of the study was to analyze the suitability of influenza treatment among children younger than 5 years hospitalized due to an influenza-like illness. We conducted a comparison of the treatment among children hospitalized in two consecutive years: 2015, when no rapid influenza diagnostic tests (RIDT) were in use, and 2016, when RIDT were implemented into a routine practice in the pediatric ward. In both seasons, nasopharyngeal swabs were collected and examined with real time qRT-PCR. In the 2015 season, influenza was diagnosed in 15/52 (28 %) children and none of them received oseltamivir, while 14/15 (93 %) patients received antibiotics. In the 2016 season, influenza was diagnosed in 11/63 (17 %) children, 7/11 (64 %) of them received oseltamivir and another 7/11 (64 %) received antibiotics. In four cases antibiotics overlapped oseltamivir. These differences in the use of oseltamivir and antibiotics were statistically significant (p < 0.05). We conclude that the implementation of RIDT improves the suitability of influenza treatment and decreases the frequency of antibiotic therapy. RIDT should be available in pediatric departments to optimize influenza treatment.


Antibiotic Therapy; Antiviral Treatment; Children; Hospitalization; Influenza-Like Illness; Neuraminidase Inhibitors

PMID: 28315128 DOI: 10.1007/5584_2016_181