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Impact of introduction of Xpert Flu assay for influenza PCR testing on obstetric patients: a quality improvement project

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  • Impact of introduction of Xpert Flu assay for influenza PCR testing on obstetric patients: a quality improvement project

    J Matern Fetal Neonatal Med. 2017 Mar 12:1-15. doi: 10.1080/14767058.2017.1306048. [Epub ahead of print]
    Impact of introduction of Xpert Flu assay for influenza PCR testing on obstetric patients: a quality improvement project.

    Linehan E1, Brennan M2, O'Rourke S3, Coughlan S4, Clooney L5, LeBlanc D6, Griffin J7, Eogan M8, Drew RJ6,9.
    Author information

    Abstract

    OBJECTIVE:

    The aim of this project was to assess the implementation of a quality improvement project regarding the introduction of on-site influenza PCR testing in a stand-alone obstetric hospital.
    METHODS:

    As part of a quality improvement project on the management of influenza in obstetric patients, the Xpert Flu assay (Cepheid, USA) was introduced on-site and it replaced the previous method of PCR testing which was off-site. The main outcome measures were duration of antimicrobials, rate of admission and administration of oseltamavir in the emergency department.
    RESULTS:

    Twenty-eight patients were included in the pre-intervention period and 45 patients were included in the post-intervention period. Following the introduction of the test there was a statistically significant reduction seen in commencement of antimicrobials (76% pre- and 33% post intervention), and also rate of admission (88% pre- and 45% post-intervention) while there was a statistically significant improvement in the commencement of oseltamavir in the Emergency Department (72% pre-and 95% post-intervention) (p < 0.01 for all outcomes).
    CONCLUSION:

    Introduction of on-site rapid influenza PCR testing can lead to a significant improvement in patient management and should be considered for introduction to other sites.


    KEYWORDS:

    GeneXpert; Influenza; PCR; Xpert Flu; obstetrics

    PMID: 28285563 DOI: 10.1080/14767058.2017.1306048
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