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Biomarkers. 2016 Dec 23:1-14. doi: 10.1080/1354750X.2016.1276626. [Epub ahead of print]
Procalcitonin for clinical decisions on influenza-like illness in emergency department during influenza A(H1N1)2009 pandemic.
Canavaggio P1, Boutolleau D2,3, Goulet H1, Riou B1,4, Hausfater P1,4.
Author information
Abstract
PURPOSE:
We aimed to determine whether serum PCT values could help in identifying flu in patient admitted to the emergency department (ED) with influenza-like illness during influenza A(H1N1)2009 pandemic.
METHODS:
An observational retrospective cohort study was performed in a referral ED for emerging infectious diseases. All patients tested for influenza A(H1N1)2009 by RT-PCR and procalcitonin between June 2009 and January 2010 were analyzed. PCT was studied for its negative predictive value of bacterial infection. Patients PCT-/RT-PCR+ were considered as true positive.
RESULTS:
On the 80 patients included, 16 were positive for influenza A(H1N1)2009 RT-PCR, all but one of them had low PCT concentrations. Conversely, 19 (30%) of the 64 patients with negative RT-PCR had elevated PCT concentrations. For a PCT threshold < 0.25 μg/L, sensitivity was 0.94, specificity 0.30, positive predictive value 0.25 and negative predictive value 0.95 for the diagnosis of flu.
CONCLUSION:
In the context of an influenza pandemic, serum PCT measurement may be useful for clinical decisions in the ED as most of RT-PCR confirmed patients have low PCT values. Patients with PCT above 0.25 μg/L are unlikely to have a unique diagnosis of flu.
KEYWORDS:
antibiotic; emergency department; flu; influenza; procalcitonin
PMID: 28010128 DOI: 10.1080/1354750X.2016.1276626
[PubMed - as supplied by publisher]
Procalcitonin for clinical decisions on influenza-like illness in emergency department during influenza A(H1N1)2009 pandemic.
Canavaggio P1, Boutolleau D2,3, Goulet H1, Riou B1,4, Hausfater P1,4.
Author information
Abstract
PURPOSE:
We aimed to determine whether serum PCT values could help in identifying flu in patient admitted to the emergency department (ED) with influenza-like illness during influenza A(H1N1)2009 pandemic.
METHODS:
An observational retrospective cohort study was performed in a referral ED for emerging infectious diseases. All patients tested for influenza A(H1N1)2009 by RT-PCR and procalcitonin between June 2009 and January 2010 were analyzed. PCT was studied for its negative predictive value of bacterial infection. Patients PCT-/RT-PCR+ were considered as true positive.
RESULTS:
On the 80 patients included, 16 were positive for influenza A(H1N1)2009 RT-PCR, all but one of them had low PCT concentrations. Conversely, 19 (30%) of the 64 patients with negative RT-PCR had elevated PCT concentrations. For a PCT threshold < 0.25 μg/L, sensitivity was 0.94, specificity 0.30, positive predictive value 0.25 and negative predictive value 0.95 for the diagnosis of flu.
CONCLUSION:
In the context of an influenza pandemic, serum PCT measurement may be useful for clinical decisions in the ED as most of RT-PCR confirmed patients have low PCT values. Patients with PCT above 0.25 μg/L are unlikely to have a unique diagnosis of flu.
KEYWORDS:
antibiotic; emergency department; flu; influenza; procalcitonin
PMID: 28010128 DOI: 10.1080/1354750X.2016.1276626
[PubMed - as supplied by publisher]