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Evaluation of the rapid influenza detection tests "GOLD SIGN FLU?" and "Quick Navi-Flu?" for detecting influenza viruses A and B antigens in adults during the influenza season

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  • Evaluation of the rapid influenza detection tests "GOLD SIGN FLU?" and "Quick Navi-Flu?" for detecting influenza viruses A and B antigens in adults during the influenza season

    Int J Infect Dis. 2016 Oct 6. pii: S1201-9712(16)31185-7. doi: 10.1016/j.ijid.2016.10.002. [Epub ahead of print]
    Evaluation of the rapid influenza detection tests "GOLD SIGN FLU?" and "Quick Navi-Flu?" for detecting influenza viruses A and B antigens in adults during the influenza season.

    Akaishi Y1, Matsumoto T2, Harada Y3, Hirayama Y3.
    Author information

    Abstract

    As the characteristics and accuracy of rapid influenza detection tests (RIDTs) vary, the development of a high-performance RIDT has been eagerly anticipated. In this study, we evaluated the new RIDT "GOLD SIGN FLU?" and the usual RIDT "Quick Navi-Flu?" in terms of detecting the influenza viruses A and B antigens in Japanese adults with influenza-like symptoms from December 2013 to March 2014. Among the 123 patients in whom nasopharyngeal swab specimens were collected, 59 tested positive (influenza A, 38; influenza B, 21) by viral isolation as the gold standard method. For "GOLD SIGN FLU?", the sensitivities were 73.7% and 81.0%, and the specificities were 97.6% and 98.0% for influenza A and B, respectively. For "Quick Navi-Flu?", the sensitivities were 86.8% and 85.7%, and the specificities were 98.8% and 100% for influenza A and B, respectively. More than 90% of the resulting line appearance time was less than 3minutes for influenza A and less than 2minutes for influenza B on the test strip of both RIDTs. "GOLD SIGN FLU?" was useful for diagnosing influenza A, and the result was readily available for influenza B particularly among adult patients. "Quick Navi-Flu?" showed better sensitivities and specificities than "GOLD SIGN FLU?".
    Copyright ? 2016. Published by Elsevier Ltd.


    KEYWORDS:

    Influenza; Rapid influenza detection test; Viral isolation

    PMID: 27720945 DOI: 10.1016/j.ijid.2016.10.002
    [PubMed - as supplied by publisher] Free full text
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