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Open Forum Infect Dis. 2016 Jan 19;3(1):ofw007. doi: 10.1093/ofid/ofw007. eCollection 2016.
A Genomic Signature of Influenza Infection Shows Potential for Presymptomatic Detection, Guiding Early Therapy, and Monitoring Clinical Responses.
McClain MT1, Nicholson BP2, Park LP3, Liu TY4, Hero AO 3rd5, Tsalik EL1, Zaas AK6, Veldman T7, Hudson LL7, Lambkin-Williams R8, Gilbert A8, Burke T7, Nichols M7, Ginsburg GS7, Woods CW1.
Author information
Abstract
Early, presymptomatic intervention with oseltamivir (corresponding to the onset of a published host-based genomic signature of influenza infection) resulted in decreased overall influenza symptoms (aggregate symptom scores of 23.5 vs 46.3), more rapid resolution of clinical disease (20 hours earlier), reduced viral shedding (total median tissue culture infectious dose [TCID50] 7.4 vs 9.7), and significantly reduced expression of several inflammatory cytokines (interferon-γ, tumor necrosis factor-α, interleukin-6, and others). The host genomic response to influenza infection is robust and may provide the means for early detection, more timely therapeutic interventions, a meaningful reduction in clinical disease, and an effective molecular means to track response to therapy.
KEYWORDS:
gene expression; genomic; influenza; oseltamivir
PMID: 26933666 [PubMed] PMCID: PMC4771939 Free PMC Article
A Genomic Signature of Influenza Infection Shows Potential for Presymptomatic Detection, Guiding Early Therapy, and Monitoring Clinical Responses.
McClain MT1, Nicholson BP2, Park LP3, Liu TY4, Hero AO 3rd5, Tsalik EL1, Zaas AK6, Veldman T7, Hudson LL7, Lambkin-Williams R8, Gilbert A8, Burke T7, Nichols M7, Ginsburg GS7, Woods CW1.
Author information
Abstract
Early, presymptomatic intervention with oseltamivir (corresponding to the onset of a published host-based genomic signature of influenza infection) resulted in decreased overall influenza symptoms (aggregate symptom scores of 23.5 vs 46.3), more rapid resolution of clinical disease (20 hours earlier), reduced viral shedding (total median tissue culture infectious dose [TCID50] 7.4 vs 9.7), and significantly reduced expression of several inflammatory cytokines (interferon-γ, tumor necrosis factor-α, interleukin-6, and others). The host genomic response to influenza infection is robust and may provide the means for early detection, more timely therapeutic interventions, a meaningful reduction in clinical disease, and an effective molecular means to track response to therapy.
KEYWORDS:
gene expression; genomic; influenza; oseltamivir
PMID: 26933666 [PubMed] PMCID: PMC4771939 Free PMC Article