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Use of ex vivo and in vitro cultures of the human respiratory tract to study the tropism and host responses of highly pathogenic avian influenza A (H5N1) and other influenza viruses

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  • Use of ex vivo and in vitro cultures of the human respiratory tract to study the tropism and host responses of highly pathogenic avian influenza A (H5N1) and other influenza viruses

    Virus Res. 2013 May 15. pii: S0168-1702(13)00078-6. doi: 10.1016/j.virusres.2013.03.003. [Epub ahead of print]
    Use of ex vivo and in vitro cultures of the human respiratory tract to study the tropism and host responses of highly pathogenic avian influenza A (H5N1) and other influenza viruses.
    Chan RW, Chan MC, Nicholls JM, Peiris JS.
    Source

    Department of Pathology, The University of Hong Kong, Hong Kong SAR; Centre of Influenza Research, The University of Hong Kong, Hong Kong SAR. Electronic address: reneewy@hku.hk.

    PMID:
    23684848
    [PubMed - as supplied by publisher]

    The tropism of influenza viruses for the human respiratory tract is a key determinant of host-range, and consequently, of pathogenesis and transmission. Insights can be obtained from clinical and autopsy studies of human disease and relevant animal models. Ex vivo cultures of the human respiratory t …
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