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Clinical factors predictive of PCR positive in pandemic H1N1 2009 influenza virus infection

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  • Clinical factors predictive of PCR positive in pandemic H1N1 2009 influenza virus infection

    Influenza Other Respi Viruses. 2011 Aug 17. doi: 10.1111/j.1750-2659.2011.00280.x. [Epub ahead of print]
    Clinical factors predictive of PCR positive in pandemic H1N1 2009 influenza virus infection.
    Phungoen P, Sawanyawisuth K, Engchanil C, Sutra S, Rangsrikajee D, Lulitanond V, Srinakarin J, Pithak P, Bourpoern J, Phondongnok S.
    Source

    Department of Emergency Medicine, Faculty of Medicine, Khon Kaen University, Khon Kaen, Thailand Department of Medicine, Faculty of Medicine, Khon Kaen University, Khon Kaen, Thailand The Research and Diagnostic Center for Emerging Infectious Diseases, Faculty of Medicine, Khon Kaen University, Khon Kaen, Thailand Department of Microbiology, Faculty of Medicine, Khon Kaen University, Khon Kaen, Thailand Department of Epidemiology, Faculty of Medicine, Khon Kaen University, Khon Kaen, Thailand Department of Radiology, Faculty of Medicine, Khon Kaen University, Khon Kaen, Thailand Laboratory Unit, Srinagarind Hospital, Faculty of Medicine, Khon Kaen University, Khon Kaen, Thailand Infectious Control Unit, Srinagarind Hospital, Faculty of Medicine, Khon Kaen University, Khon Kaen, Thailand.
    Abstract

    Please cite this paper as: Phungoen et al. (2011) Clinical factors predictive of PCR positive in pandemic H1N1 2009 influenza virus infection. Influenza and Other Respiratory Viruses DOI: 10.1111/j.1750-2659.2011.00280.x. Objective  Pandemic H1N1 2009 influenza virus (H1N1) has been spreading globally. Clinical features might be predictive and may be different among countries. Even though the PCR test is a confirmatory test for this viral infection, it is expensive and limited in most Thai health care facilities. We studied predictive factors of PCR positive in H1N1 suspected patients. Methods  Consecutive patients who had influenza-like illness less than seven days and had been tested for H1N1 by the real-time PCR method between May and July 2009 were enrolled. Clinical data was collected and compared between those who had positive and negative PCR tests. Results  There were 6494 patients had flu-like symptoms. Of those, 166 patients were done PCR test and 75 patients (45?18%) had positive PCR test. There were four predictors for positive PCR test including history of contact with confirmed H1N1 patients, headache, body temperature, and coryza with the adjusted odds ratio (95% confidence interval) of 2?84 (1?09-7?40), 6?25 (1?42-27?49), 1?69 (1?08-2?66), and 0?31 (0?12-0?79), respectively. Conclusions  Clinical factors can be both suggestive and protective factors for H1N1 infection. These factors may be helpful in clinical practice to assess the possibility of the H1N1 infection in people who are at risk; particularly in resource-limited health care facilities.

    ? 2011 Blackwell Publishing Ltd.

    PMID:
    21848617
    [PubMed - as supplied by publisher]

    Clinical factors can be both suggestive and protective factors for H1N1 infection. These factors may be helpful in clinical practice to assess the possibility of the H1N1 infection in people who are at risk; particularly in resource-limited health care facilities.
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