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Euro Surveill. Letter to the editor. Virological analysis of fatal influenza cases in the United Kingdom during the early wave of influenza in winter 2010/11
Letter to the editor. Virological analysis of fatal influenza cases in the United Kingdom during the early wave of influenza in winter 2010/11 (Euro Surveill., extract, edited)
[Source: Eurosurveillance, full text: <cite cite="http://www.eurosurveillance.org/ViewArticle.aspx?ArticleId=19774">Eurosurveillance - View Article</cite>. Extract, edited.]
Eurosurveillance, Volume 16, Issue 4, 27 January 2011
Letters
Letter to the editor. Virological analysis of fatal influenza cases in the United Kingdom during the early wave of influenza in winter 2010/11
F Baldanti 1, A Zanetti 2
1. Molecular Virology Unit, Fondazione IRCCS Policlinico San Matteo, Pavia, Italy
2. Department of Public Health, Microbiology and Virology, University of Milan, Milan, Italy
Citation style for this article: Baldanti F, Zanetti A. Letter to the editor. Virological analysis of fatal influenza cases in the United Kingdom during the early wave of influenza in winter 2010/11. Euro Surveill. 2011;16(4):pii=19774. Available online: http://www.eurosurveillance.org/View...rticleId=19774
Date of submission: 19 January 2011
To the editor:
In response to the paper by Ellis et al. [1], published in Eurosurveillance Volume 16, issue 1, we would like to make a few observations. D222G/N substitutions in the haemagglutinin of influenza A(H1N1)2009 strains have been associated with increased virulence [2-4]. An enhanced binding affinity of the mutated haemagglutinin to the α-2,3 sialic acid receptor rather than to the α-2,6 sialic acid receptor has been postulated to be the basis of the increased virulence of D222G/N mutants [3]. The α-2,3 sialic acid receptor is present at higher density on the surface of the cells of the lower respiratory tract tissues whereas the α-2,6 sialic acid receptor is present at higher density on the surface of cells of the upper respiratory tract tissues.
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[Source: Eurosurveillance, full text: <cite cite="http://www.eurosurveillance.org/ViewArticle.aspx?ArticleId=19774">Eurosurveillance - View Article</cite>. Extract, edited.]
Eurosurveillance, Volume 16, Issue 4, 27 January 2011
Letters
Letter to the editor. Virological analysis of fatal influenza cases in the United Kingdom during the early wave of influenza in winter 2010/11
F Baldanti 1, A Zanetti 2
1. Molecular Virology Unit, Fondazione IRCCS Policlinico San Matteo, Pavia, Italy
2. Department of Public Health, Microbiology and Virology, University of Milan, Milan, Italy
Citation style for this article: Baldanti F, Zanetti A. Letter to the editor. Virological analysis of fatal influenza cases in the United Kingdom during the early wave of influenza in winter 2010/11. Euro Surveill. 2011;16(4):pii=19774. Available online: http://www.eurosurveillance.org/View...rticleId=19774
Date of submission: 19 January 2011
To the editor:
In response to the paper by Ellis et al. [1], published in Eurosurveillance Volume 16, issue 1, we would like to make a few observations. D222G/N substitutions in the haemagglutinin of influenza A(H1N1)2009 strains have been associated with increased virulence [2-4]. An enhanced binding affinity of the mutated haemagglutinin to the α-2,3 sialic acid receptor rather than to the α-2,6 sialic acid receptor has been postulated to be the basis of the increased virulence of D222G/N mutants [3]. The α-2,3 sialic acid receptor is present at higher density on the surface of the cells of the lower respiratory tract tissues whereas the α-2,6 sialic acid receptor is present at higher density on the surface of cells of the upper respiratory tract tissues.
(...)
-
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