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Statistical modelling of data showing pandemic H1N1 2009 swine influenza a virus infection kinetics in vaccinated pigs

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  • Statistical modelling of data showing pandemic H1N1 2009 swine influenza a virus infection kinetics in vaccinated pigs


    Data Brief. 2019 Sep 28;27:104576. doi: 10.1016/j.dib.2019.104576. eCollection 2019 Dec. Statistical modelling of data showing pandemic H1N1 2009 swine influenza a virus infection kinetics in vaccinated pigs.

    Canini L1, Everett HE2, Aramouni M3, Coward V2, Ramsay A2, Kelly M2, Morgan S4, Tchilian E4, Gilbert S3, Charleston B4, Brown IH2, Brookes SM2, Woolhouse MEJ1.
    Author information

    1 University of Edinburgh, University of Edinburgh, Charlotte Auerbach Road, Edinburgh, EH9 3FL, UK. 2 Virology Department, Animal and Plant Health Agency (APHA-Weybridge), New Haw, Addlestone, KT15 3NB, UK. 3 The Jenner Institute, University of Oxford, ORCRB, Roosevelt Drive, Oxford, OX3 7DQ, UK. 4 The Pirbright Institute, Ash Road, Pirbright, Woking, GU24 0NF, UK.

    Abstract

    A swine influenza A pandemic 2009 H1N1 (pH1N1) virus was used in a pig challenge model to investigate the efficacy of whole inactivated vaccines homologous or heterologous to the challenge virus as well as a commercial vaccine. Nasal shedding of viral RNA was monitored daily by real-time, quantitative RT-PCR (RRT-qPCR) as detailed (1). Here we report the statistical modelling of the viral RNA shedding kinetics.
    Crown Copyright ? 2019 Published by Elsevier Inc.


    KEYWORDS:

    Pandemic 2009 swine influenza a virus; Statistical modelling RRT-qPCR; Viral kinetics; Whole inactivated vaccine

    PMID: 31687431 PMCID: PMC6820103 DOI: 10.1016/j.dib.2019.104576
    Free PMC Article

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