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Influenza A (H1N1) pdm09 virus infection in a patient with incomplete Kawasaki disease: A case report

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  • Influenza A (H1N1) pdm09 virus infection in a patient with incomplete Kawasaki disease: A case report

    Medicine (Baltimore). 2019 Apr;98(15):e15009. doi: 10.1097/MD.0000000000015009.
    Influenza A (H1N1) pdm09 virus infection in a patient with incomplete Kawasaki disease: A case report.

    Wang J1, Sun F2, Deng HL1, Liu RQ1.
    Author information

    Abstract

    RATIONALE:

    Kawasaki disease (KD) is a vasculitic illness of childhood associated with coronary artery dilatation, coronary artery aneurysm, arrhythmia, sudden death, and other serious cardiovascular diseases. Up to date, the etiology of KD remains unclear; however, epidemiological characteristics indicate that it may be related to as-yet-undefined pathogen infection.
    PATIENT CONCERNS:

    A 19-month-old boy had a fever of unknown origin at 38?C for 9 days without rash, runny nose and cough.
    DIAGNOSIS:

    The boy was diagnosed with incomplete KD (IKD) coincident with influenza A (H1N1) pdm09 virus.
    INTERVENTIONS:

    He was received treatments including human immunoglobulin (2 g/kg), aspirin (30∼50 mg/kg.d), and dipyridamole (3∼5 mg/kg.d).
    OUTCOMES:

    After 24 hours of human immunoglobulin infusion, his body temperature returned normal. After hospitalization for 6 days, his symptoms disappeared and discharged from the hospital.
    LESSONS:

    More attention should be paid to the correlation between KD and pathogen infection, especially the new influenza virus H1N1. The potential mechanism underlying viral infection-mediated KD is worthy of further investigation, which may provide scientific evidence for the pathogenesis of KD.


    PMID: 30985646 DOI: 10.1097/MD.0000000000015009
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