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J Immunol Res. 2018 Feb 25;2018:3174868. doi: 10.1155/2018/3174868. eCollection 2018.
An Increased Frequency in HLA Class I Alleles and Haplotypes Suggests Genetic Susceptibility to Influenza A (H1N1) 2009 Pandemic: A Case-Control Study.
Falf?n-Valencia R1, Narayanankutty A1, Res?ndiz-Hern?ndez JM1, P?rez-Rubio G1, Ram?rez-Venegas A2, Nava-Quiroz KJ1, Bautista-F?lix NE2, Vargas-Alarc?n G3, Castillejos-L?pez MDJ4, Hern?ndez A4.
Author information
Abstract
Background:
The influenza A H1N1/09 pandemic infected a small number of exposed individuals, which suggests the involvement of genetic factors. There are scarce data available on classical HLA class I association with the influenza A H1N1/09 pandemic.
Methods:
We analyzed the frequency of classical HLA class I alleles and haplotypes in A H1N1/09 influenza in a case-control study including 138 influenza patients (INF-P) and 225 asymptomatic healthy contacts (INF-C) simultaneously recruited. HLA class I typing was performed by high-resolution sequence-based typing method.
Results:
Our analysis revealed higher frequency of C∗07:02:01, B∗39:06:02, C∗03:02:01, B∗44:03:01, B∗51:01:05, and B∗73:01 (p < 0.05; OR = 1.84-9.98) and of two haplotypes-A∗68:01:02-C∗07:02:01 (p = 1.05E - 05; OR = 23.99) and B∗35:01:01-C∗07:02.01 (p = 4.15E - 04, OR = 2.15)-in A H1N1/09 influenza subjects. A∗68:01:01 was exclusively present only in the INF-P group (5/138). A decrease in the frequency of C∗03:03:01, A∗11:01:01, B∗39:01:01, A∗24:02:01, C∗03:04:01, B∗51:01:01, and C∗07:01:01 (p < 0.05; OR = 0.12-0.52) and of haplotypes A∗02:01:01-B∗35:01:01-C∗04:01:01, A∗24:02:01-B∗35:01:01, B∗39:01:01-C∗07:02:01, and B∗40:02:01-C∗03:04:01 (p < 0.05; OR = 0.08-0.22) were observed in INF-P group.
Conclusion:
Selective classical HLA class I allele and haplotype combinations predispose individuals towards susceptibility or protection against the influenza A H1N1/09 pandemic. This work has significant implications for accessing population transmission risk for A H1N1/09 or a similar strain breakout in the future.
PMID: 29682588 PMCID: PMC5845504 DOI: 10.1155/2018/3174868
An Increased Frequency in HLA Class I Alleles and Haplotypes Suggests Genetic Susceptibility to Influenza A (H1N1) 2009 Pandemic: A Case-Control Study.
Falf?n-Valencia R1, Narayanankutty A1, Res?ndiz-Hern?ndez JM1, P?rez-Rubio G1, Ram?rez-Venegas A2, Nava-Quiroz KJ1, Bautista-F?lix NE2, Vargas-Alarc?n G3, Castillejos-L?pez MDJ4, Hern?ndez A4.
Author information
Abstract
Background:
The influenza A H1N1/09 pandemic infected a small number of exposed individuals, which suggests the involvement of genetic factors. There are scarce data available on classical HLA class I association with the influenza A H1N1/09 pandemic.
Methods:
We analyzed the frequency of classical HLA class I alleles and haplotypes in A H1N1/09 influenza in a case-control study including 138 influenza patients (INF-P) and 225 asymptomatic healthy contacts (INF-C) simultaneously recruited. HLA class I typing was performed by high-resolution sequence-based typing method.
Results:
Our analysis revealed higher frequency of C∗07:02:01, B∗39:06:02, C∗03:02:01, B∗44:03:01, B∗51:01:05, and B∗73:01 (p < 0.05; OR = 1.84-9.98) and of two haplotypes-A∗68:01:02-C∗07:02:01 (p = 1.05E - 05; OR = 23.99) and B∗35:01:01-C∗07:02.01 (p = 4.15E - 04, OR = 2.15)-in A H1N1/09 influenza subjects. A∗68:01:01 was exclusively present only in the INF-P group (5/138). A decrease in the frequency of C∗03:03:01, A∗11:01:01, B∗39:01:01, A∗24:02:01, C∗03:04:01, B∗51:01:01, and C∗07:01:01 (p < 0.05; OR = 0.12-0.52) and of haplotypes A∗02:01:01-B∗35:01:01-C∗04:01:01, A∗24:02:01-B∗35:01:01, B∗39:01:01-C∗07:02:01, and B∗40:02:01-C∗03:04:01 (p < 0.05; OR = 0.08-0.22) were observed in INF-P group.
Conclusion:
Selective classical HLA class I allele and haplotype combinations predispose individuals towards susceptibility or protection against the influenza A H1N1/09 pandemic. This work has significant implications for accessing population transmission risk for A H1N1/09 or a similar strain breakout in the future.
PMID: 29682588 PMCID: PMC5845504 DOI: 10.1155/2018/3174868