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J Infect Dis. 2018 Apr 12. doi: 10.1093/infdis/jiy218. [Epub ahead of print]
H1N1pdm09 Influenza Virus and its Descendants Lack Extra-Epitopic Amino Acid Residues Associated with Reduced Recognition by M158-66-specific CD8+ T-cells.
van de Sandt CE1, Sagong KA1, Pronk MR1, Bestebroer TM1, Spronken MI1, Koopmans MPG1, Fouchier RAM1, Rimmelzwaan GF1.
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Abstract
Extra-epitopic amino acid residues affect recognition of human influenza A viruses (IAVs) by CD8+ T-lymphocytes (CTLs) specific for the highly conserved HLA-A*0201 restricted M158-66 epitope located in the matrix 1 (M1) protein. These residues are absent in the M1 protein of the 2009-pandemic IAV (H1N1pdm09). Consequently, stimulation with M1 protein of H1N1pdm09 IAV resulted in stronger activation and lytic activity of M158-66-specific CTLs than stimulation with seasonal H3N2 IAVs. During more than six years of circulation in the human population, descendants of the H1N1pdm09 virus had accumulated four other amino acid substitutions. However, these did not affect M158-66-specific CTL activation.
PMID: 29659927 DOI: 10.1093/infdis/jiy218
H1N1pdm09 Influenza Virus and its Descendants Lack Extra-Epitopic Amino Acid Residues Associated with Reduced Recognition by M158-66-specific CD8+ T-cells.
van de Sandt CE1, Sagong KA1, Pronk MR1, Bestebroer TM1, Spronken MI1, Koopmans MPG1, Fouchier RAM1, Rimmelzwaan GF1.
Author information
Abstract
Extra-epitopic amino acid residues affect recognition of human influenza A viruses (IAVs) by CD8+ T-lymphocytes (CTLs) specific for the highly conserved HLA-A*0201 restricted M158-66 epitope located in the matrix 1 (M1) protein. These residues are absent in the M1 protein of the 2009-pandemic IAV (H1N1pdm09). Consequently, stimulation with M1 protein of H1N1pdm09 IAV resulted in stronger activation and lytic activity of M158-66-specific CTLs than stimulation with seasonal H3N2 IAVs. During more than six years of circulation in the human population, descendants of the H1N1pdm09 virus had accumulated four other amino acid substitutions. However, these did not affect M158-66-specific CTL activation.
PMID: 29659927 DOI: 10.1093/infdis/jiy218