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Influenza Other Respir Viruses. 2017 Aug 9. doi: 10.1111/irv.12469. [Epub ahead of print]
Characterization of influenza A(H1N1)pdm09 viruses isolated from Nepalese and Indian outbreak patients in early 2015.
Nakamura K1, Shirakura M1, Fujisaki S1, Kishida N1, Burke DF2, Smith DJ2, Kuwahara T1, Takashita E1, Takayama I1, Nakauchi M1, Chadha M3, Potdar V3, Bhushan A3, Upadhyay BP4, Shakya G4, Odagiri T1, Kageyama T1, Watanabe S1.
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Abstract
We characterized influenza A(H1N1)pdm09 isolates from large-scale outbreaks that occurred in Nepal and India in early 2015. Although no specific viral features, which may have caused the outbreaks, were identified, an S84N substitution in hemagglutinin was frequently observed. Chronological phylogenetic analysis revealed that these Nepalese and Indian viruses possessing the S84N substitution constitute potential ancestors of the novel genetic subclade 6B.1 virus that spread globally in the following (2015/16) influenza season. Thus, active surveillance of circulating influenza viruses in the Southern Asia region, including Nepal and India, would be beneficial for detecting novel variant viruses prior to their worldwide spread.
? 2017 The Authors. Influenza and Other Respiratory Viruses Published by John Wiley & Sons Ltd.
KEYWORDS:
India; Nepal; influenza A(H1N1)pdm09 virus; outbreak
PMID: 28792671 DOI: 10.1111/irv.12469
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Characterization of influenza A(H1N1)pdm09 viruses isolated from Nepalese and Indian outbreak patients in early 2015.
Nakamura K1, Shirakura M1, Fujisaki S1, Kishida N1, Burke DF2, Smith DJ2, Kuwahara T1, Takashita E1, Takayama I1, Nakauchi M1, Chadha M3, Potdar V3, Bhushan A3, Upadhyay BP4, Shakya G4, Odagiri T1, Kageyama T1, Watanabe S1.
Author information
Abstract
We characterized influenza A(H1N1)pdm09 isolates from large-scale outbreaks that occurred in Nepal and India in early 2015. Although no specific viral features, which may have caused the outbreaks, were identified, an S84N substitution in hemagglutinin was frequently observed. Chronological phylogenetic analysis revealed that these Nepalese and Indian viruses possessing the S84N substitution constitute potential ancestors of the novel genetic subclade 6B.1 virus that spread globally in the following (2015/16) influenza season. Thus, active surveillance of circulating influenza viruses in the Southern Asia region, including Nepal and India, would be beneficial for detecting novel variant viruses prior to their worldwide spread.
? 2017 The Authors. Influenza and Other Respiratory Viruses Published by John Wiley & Sons Ltd.
KEYWORDS:
India; Nepal; influenza A(H1N1)pdm09 virus; outbreak
PMID: 28792671 DOI: 10.1111/irv.12469
Free full text