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Bull Exp Biol Med. 2017 Mar 30. doi: 10.1007/s10517-017-3678-1. [Epub ahead of print]
Study of SMAD-Dependent Signal Pathway in the Development of Early Pulmonary Fibrosis in Mice Infected with Influenza A/H1N1 Virus.
Shatskaya EV1, Kovner AV2, Potapova OV2, Cherdantseva LA2, Shkurupy VA2, Shestopalov AM2.
Author information
Abstract
Early fibrosis of the visceral organs is one of the main complications of infection caused by influenza A virus. Structural manifestations and molecular regulators of the epithelialmesenchymal transformation as a possible mechanism of fibrosis progression were studied in mice infected with influenza A/H1N1 A/Tomsk/13/2010 virus. We found early fibrosis of the lungs against the background of minor changes in fibroblast count. However, enhanced expression of TGF-β and SMAD-2 by macrophages and alveolocytes attested to possible development of epithelial-mesenchymal transformation and its contribution to activation of fibrogenesis process in the lungs.
KEYWORDS:
SMAD-2; epithelial-mesenchymal transformations; fibrosis; influenza A/H1N1 A/Tomsk/13/2010 virus; lungs
PMID: 28361411 DOI: 10.1007/s10517-017-3678-1
Study of SMAD-Dependent Signal Pathway in the Development of Early Pulmonary Fibrosis in Mice Infected with Influenza A/H1N1 Virus.
Shatskaya EV1, Kovner AV2, Potapova OV2, Cherdantseva LA2, Shkurupy VA2, Shestopalov AM2.
Author information
Abstract
Early fibrosis of the visceral organs is one of the main complications of infection caused by influenza A virus. Structural manifestations and molecular regulators of the epithelialmesenchymal transformation as a possible mechanism of fibrosis progression were studied in mice infected with influenza A/H1N1 A/Tomsk/13/2010 virus. We found early fibrosis of the lungs against the background of minor changes in fibroblast count. However, enhanced expression of TGF-β and SMAD-2 by macrophages and alveolocytes attested to possible development of epithelial-mesenchymal transformation and its contribution to activation of fibrogenesis process in the lungs.
KEYWORDS:
SMAD-2; epithelial-mesenchymal transformations; fibrosis; influenza A/H1N1 A/Tomsk/13/2010 virus; lungs
PMID: 28361411 DOI: 10.1007/s10517-017-3678-1