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Impacts of different expressions of PA-X protein on 2009 pandemic H1N1 virus replication, pathogenicity and host immune responses

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  • Impacts of different expressions of PA-X protein on 2009 pandemic H1N1 virus replication, pathogenicity and host immune responses

    Virology. 2017 Jan 28;504:25-35. doi: 10.1016/j.virol.2017.01.015. [Epub ahead of print]
    Impacts of different expressions of PA-X protein on 2009 pandemic H1N1 virus replication, pathogenicity and host immune responses.

    Lee J1, Yu H2, Li Y1, Ma J1, Lang Y1, Duff M1, Henningson J1, Liu Q2, Li Y1, Nagy A1, Bawa B1, Li Z3, Tong G3, Richt JA1, Ma W4.
    Author information

    Abstract

    Although several studies have investigated the functions of influenza PA-X, the impact of different expressions of PA-X protein including full-length, truncated or PA-X deficient forms on virus replication, pathogenicity and host response remains unclear. Herein, we generated two mutated viruses expressing a full-length or deficient PA-X protein based on the A/California/04/2009 (H1N1) virus that expresses a truncated PA-X to understand three different expressions of PA-X protein on virus replication, pathogenicity and host immune responses. The results showed that expression of either full-length or truncated PA-X protein enhanced viral replication and pathogenicity as well as reduced host innate immune response in mice by host shutoff activity when compared to the virus expressing the deficient PA-X form. Furthermore, the full-length PA-X expression exhibited a greater effect on virus pathogenicity than the truncated PA-X form. Our results provide novel insights of PA-X on viral replication, pathogenicity and host immune responses.
    Copyright ? 2017. Published by Elsevier Inc.


    KEYWORDS:

    Host immune response; Influenza A virus; PA-X; Virus replication

    PMID: 28142079 DOI: 10.1016/j.virol.2017.01.015
    [PubMed - as supplied by publisher]
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