Emerg Infect Dis. Clinical and Epidemiologic Characteristics of 3 Early Cases of Influenza A Pandemic (H1N1) 2009 Virus Infection, People?s Republic of China, 2009

[Giuseppe]

Clinical and Epidemiologic Characteristics of 3 Early Cases of Influenza A Pandemic (H1N1) 2009 Virus Infection, People?s Republic of China, 2009 (EID, Abstract, edited)

[Original Full Document: LINK. EDITED.]

DOI: 10.3201/eid1509.090794

Suggested citation for this article: Bin C, Xingwang L, Yuelong S, Nan J, Shijun C, Xiayuan X, et al; National Influenza A Pandemic (H1N1) 2009 Clinical Investigation Group. Clinical and epidemiologic characteristics of 3 early cases of influenza A pandemic (H1N1) 2009 virus, People?s Republic of China. Emerg Infect Dis. 2009 Sep; [Epub ahead of print]


Clinical and Epidemiologic Characteristics of 3 Early Cases of Influenza A Pandemic (H1N1) 2009 Virus Infection, People?s Republic of China, 2009

Cao Bin,1 Li Xingwang,(1) Shu Yuelong, Jiang Nan, Chen Shijun, Xu Xiayuan, and Wang Chan, for the National Influenza A Pandemic (H1N1) 2009 Clinical Investigation Group(2)

Author affiliations:
Capital Medical University, Beijing, People's Republic of China (C. Bin, W. Chen); Beijing Ditan Hospital, Beijing (L. Xingwang); Chinese Center for Disease Control and Prevention, Beijing (S. Yuelong); Sichuan Province People?s Hospital, Chengdu, People's Republic of China (J. Nan); Jinan Infectious Diseases Hospital, Jinan, People's Republic of China (C. Shijun); and Peking University, Beijing (X. Xiaoyuan)

(1) These authors contributed equally to this manuscript.
(2) The National Influenza A Pandemic (H1N1) 2009 Clinical Investigation Group: Wang Chen, Cao Bin, Cao Zhixin, Tong Zhaohui (Beijing Chaoyang Hospital, Capital Medical University); Li Xingwang, Zhang Ming, Guo Limin, Chen Zhihai (Beijing Ditan Hospital); Chen Hong (Chengdu Infectious Diseases Hospital); Chen Shijun, Gai Zhongtao (Jinan Infectious Diseases Hospital); Xu Xiaoyuan, Wan Hua, Zheng Bo, Wang Guangfa (Peking University, First Hospital); Jiang Nan (Sichuan Province People?s Hospital); Wu Hao (Beijing Youan Hospital, Capital Medical University); Gao Zhancheng (Peking University, People?s Hospital); Zhao Mingwu (Peking University, Third Hospital); Liang Zongan (Sichuang University Huaxi Medical College); Gao Dachuan (Jinan Chest Hospital); Shu Yuelong, Zhang Weidong, Zhang Yanping (Chinese Center for Disease Control and Prevention);. Deng Guohua (Peking Union Medical College Hospital); Ren Lili (Chinese Academy of Medical Sciences); Zhao Min (Military 302 Hospital, Beijing); Zhu Qingyu (Academy of Military Medical Sciences).


On May 7, 2009, a national network was organized in the People?s Republic of China for the surveillance, reporting, diagnosis, and treatment of influenza A pandemic (H1N1) 2009 virus infection (pandemic [H1N1] 2009). Persons with suspected cases are required to report to the Chinese Center for Disease Control and Prevention and the Ministry of Health within 24 hours; the patient?s close contacts are then traced and placed in quarantine for 7 days.

We report 3 confirmed early cases of pandemic (H1N1) 2009.

Two cases were imported from United States; the other was imported from Canada. The patients exhibited fever and signs and other symptoms that were indistinguishable from those of seasonal influenza. Serial virologic monitoring of pharyngeal swabs showed that they were negative for pandemic (H1N1) 2009 virus by real-time reverse transcription?PCR 4?6 days after onset of illness. One close contact whose sample tested positive for pandemic (H1N1) 2009 virus had no symptoms during quarantine. A national network is essential for controlling pandemic (H1N1) 2009.

(...)

-
-----

[gsgs]

Re: Emerg Infect Dis. Clinical and Epidemiologic Characteristics of 3 Early Cases of Influenza A Pandemic (H1N1) 2009 Virus Infection, People?s Republic of China, 2009

only 1 sample from a total of 186 close contacts tested positive
for pandemic (H1N1) 2009 virus by real-time RT-PCR.
This sample came from the 48-year-old mother of patient 3,
[mother of A/Beijing/1] who had lived with patient 3 for 2 days
before her illness and had taken care of her 2 days after her
illness began. On the fifth day (May 16) after exposure to
patient 3, the woman's sample became positive (table 3).
As with all the other close contacts, this woman had no
fever or ILI-symptoms.





...average time of shedding is 4-6 days...
...risk of transmission is greatest in households...

[the virus of patient 3 (Beijing/1) is strangely similar to
Narita/1 , who returned from Canada to Japan.
It also has strangely few mutations from the **-index,
suggesting that it survived in the environment for some
time(weeks,months) without replicating/mutating]