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Influenza Other Respir Viruses. 2014 May;8(3):339-46. doi: 10.1111/irv.12241.
Neurological events related to influenza A (H1N1) pdm09.
C?rdenas G, Soto-Hern?ndez JL, D?az-Alba A, Ugalde Y, M?rida-Puga J, Rosetti M, Sciutto E.
Abstract
OBJECTIVES:
To review neurological complications after the influenza A (H1N1) pdm09, highlighting the clinical differences between patients with post-vaccine or viral infection.
DESIGN:
A search on Medline, Ovid, EMBASE, and PubMed databases using the keywords ?neurological complications of Influenza AH1N1? or ?post-vaccine Influenza AH1N1.?
SETTING:
Only papers written in English, Spanish, German, French, Portuguese, and Italian published from March 2009 to December 2012 were included.
SAMPLE:
We included 104 articles presenting a total of 1636 patient cases. In addition, two cases of influenza vaccine-related neurological events from our neurological care center, arising during the period of study, were also included.
MAIN OUTCOME MEASURES:
Demographic data and clinical diagnosis of neurological complications and outcomes: death, neurological sequelae or recovery after influenza A (H1N1) pdm09 vaccine or infection.
RESULTS:
The retrieved cases were divided into two groups: the postvaccination group, with 287 patients, and the viral infection group, with 1349 patients. Most patients in the first group were adults. The main neurological complications were Guillain-Barre syndrome (GBS) or polyneuropathy (125), and seizures (23). All patients survived. Pediatric patients were predominant in the viral infection group. In this group, 60 patients (4.7%) died and 52 (30.1%) developed permanent sequelae. A wide spectrum of neurological complications was observed.
CONCLUSIONS:
Fatal cases and severe, permanent, neurological sequelae were observed in the infection group only. Clinical outcome was more favorable in the post-vaccination group. In this context, the relevance of an accurate neurological evaluation is demonstrated for all suspicious cases, as well as the need of an appropriate long-term clinical and imaging follow-up of infection and post-vaccination events related to influenza A (H1N1) pdm09, to clearly estimate the magnitude of neurological complications leading to permanent disability.
PMID:
24895698
[PubMed - in process]
Neurological events related to influenza A (H1N1) pdm09.
C?rdenas G, Soto-Hern?ndez JL, D?az-Alba A, Ugalde Y, M?rida-Puga J, Rosetti M, Sciutto E.
Abstract
OBJECTIVES:
To review neurological complications after the influenza A (H1N1) pdm09, highlighting the clinical differences between patients with post-vaccine or viral infection.
DESIGN:
A search on Medline, Ovid, EMBASE, and PubMed databases using the keywords ?neurological complications of Influenza AH1N1? or ?post-vaccine Influenza AH1N1.?
SETTING:
Only papers written in English, Spanish, German, French, Portuguese, and Italian published from March 2009 to December 2012 were included.
SAMPLE:
We included 104 articles presenting a total of 1636 patient cases. In addition, two cases of influenza vaccine-related neurological events from our neurological care center, arising during the period of study, were also included.
MAIN OUTCOME MEASURES:
Demographic data and clinical diagnosis of neurological complications and outcomes: death, neurological sequelae or recovery after influenza A (H1N1) pdm09 vaccine or infection.
RESULTS:
The retrieved cases were divided into two groups: the postvaccination group, with 287 patients, and the viral infection group, with 1349 patients. Most patients in the first group were adults. The main neurological complications were Guillain-Barre syndrome (GBS) or polyneuropathy (125), and seizures (23). All patients survived. Pediatric patients were predominant in the viral infection group. In this group, 60 patients (4.7%) died and 52 (30.1%) developed permanent sequelae. A wide spectrum of neurological complications was observed.
CONCLUSIONS:
Fatal cases and severe, permanent, neurological sequelae were observed in the infection group only. Clinical outcome was more favorable in the post-vaccination group. In this context, the relevance of an accurate neurological evaluation is demonstrated for all suspicious cases, as well as the need of an appropriate long-term clinical and imaging follow-up of infection and post-vaccination events related to influenza A (H1N1) pdm09, to clearly estimate the magnitude of neurological complications leading to permanent disability.
PMID:
24895698
[PubMed - in process]
