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APMIS. 2013 Jun 12. doi: 10.1111/apm.12111. [Epub ahead of print]
Lower mannose-binding lectin contributes to deleterious H1N1 2009 infection in children.
Gao L, Shang S, Zhang C, Tong M, Chen Y.
Source
Children's Hospital of Zhejiang University Medical College, Hangzhou, China.
Abstract
Mannose-binding lectin (MBL) has broad range of activity against viruses through the mechanisms of neutralization, opsonization, and complement activation. Prior studies have demonstrated that MBL inactivated the season's influenza virus. Due to the fact that children have no neutralizing antibody against H1N1 2009 virus, innate immunity may be crucial in the defense against influenza. Therefore, we studied whether MBL levels played a role in H1N1 2009 infection in children. In a prospective survey, we revealed that MBL levels in ICU influenza cases were significantly lower than in children with influenza from infection disease ward. MBL may be involved in innate immune responses to H1N1 2009 infection in children.
? 2013 APMIS Published by John Wiley & Sons Ltd.
PMID:
23755909
[PubMed - as supplied by publisher]
Lower mannose-binding lectin contributes to deleterious H1N1 2009 infection in children.
Gao L, Shang S, Zhang C, Tong M, Chen Y.
Source
Children's Hospital of Zhejiang University Medical College, Hangzhou, China.
Abstract
Mannose-binding lectin (MBL) has broad range of activity against viruses through the mechanisms of neutralization, opsonization, and complement activation. Prior studies have demonstrated that MBL inactivated the season's influenza virus. Due to the fact that children have no neutralizing antibody against H1N1 2009 virus, innate immunity may be crucial in the defense against influenza. Therefore, we studied whether MBL levels played a role in H1N1 2009 infection in children. In a prospective survey, we revealed that MBL levels in ICU influenza cases were significantly lower than in children with influenza from infection disease ward. MBL may be involved in innate immune responses to H1N1 2009 infection in children.
? 2013 APMIS Published by John Wiley & Sons Ltd.
PMID:
23755909
[PubMed - as supplied by publisher]
