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Bing Du Xue Bao. 2013 Mar;29(2):143-7.
[Emerged Pdm09 influenza virus increased purifying selection of seasonal H1N1 influenza virus].
[Article in Chinese]
Lan Y, Huang WJ, Sui HT, Li XY, Zhao X, Li M, Chen YY, Guo JF, Cheng YH, Tan MJ, Wang Z, Xiao N, Wei HJ, Wang DY, Shu YL.
Source
Chinese National Influenza Center, National Institute for Viral Disease Control and Prevention, China CDC, Beijing 102206, China. lanyu@cnic.org.cn
Abstract
Pdm09 virus outbreak occurred in Mainland China in May 2009, a few months later, the prevalence of seasonal H1N1(sH1N1) influenza virus that already circulated in human for tens of years began to decline and disappeared afterwards. To identify the reason for the rapid decline of sH1N1 in mainland China, we sequenced the HA1 of sH1N1 during 2006-2011, and then analyzed the selective pressure in different phases. Our results showed before Pdm09 outbreak, the omega value was 0. 36 while after Pdm09 outbreak the omega value was 0. 28 and significant difference (t test, P<0. 05) was identified. We concluded that sH1N1 obtained stronger purifying selection after Pdm09 outbreak in China. This might one of the major reasons causing the disappearance of sH1N1 in human.
PMID:
23757844
[PubMed - in process]
[Emerged Pdm09 influenza virus increased purifying selection of seasonal H1N1 influenza virus].
[Article in Chinese]
Lan Y, Huang WJ, Sui HT, Li XY, Zhao X, Li M, Chen YY, Guo JF, Cheng YH, Tan MJ, Wang Z, Xiao N, Wei HJ, Wang DY, Shu YL.
Source
Chinese National Influenza Center, National Institute for Viral Disease Control and Prevention, China CDC, Beijing 102206, China. lanyu@cnic.org.cn
Abstract
Pdm09 virus outbreak occurred in Mainland China in May 2009, a few months later, the prevalence of seasonal H1N1(sH1N1) influenza virus that already circulated in human for tens of years began to decline and disappeared afterwards. To identify the reason for the rapid decline of sH1N1 in mainland China, we sequenced the HA1 of sH1N1 during 2006-2011, and then analyzed the selective pressure in different phases. Our results showed before Pdm09 outbreak, the omega value was 0. 36 while after Pdm09 outbreak the omega value was 0. 28 and significant difference (t test, P<0. 05) was identified. We concluded that sH1N1 obtained stronger purifying selection after Pdm09 outbreak in China. This might one of the major reasons causing the disappearance of sH1N1 in human.
PMID:
23757844
[PubMed - in process]
