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Thorax. Obesity and susceptibility to severe outcomes following respiratory viral infection
[Source: Thorax, full text: (LINK). Abstract, edited.]
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<CITE><ABBR>Thorax</ABBR> doi:10.1136/thoraxjnl-2012-203009 </CITE>
<CITE></CITE>
<CITE></CITE>Chest clinic / Basic science for the chest physician
Obesity and susceptibility to severe outcomes following respiratory viral infection
Mark H Almond 1,2, Michael R Edwards 1, Wendy S Barclay 2, Sebastian L Johnston 1
Author Affiliations: <SUP>1</SUP>Airway Disease Infection Section, National Heart and Lung Institute, Imperial College London, UK <SUP>2</SUP>Department of Influenza, Imperial College London, London, UK
Correspondence to Professor Sebastian L Johnston, Airway Disease Infection Section, National Heart and Lung Institute, Imperial College London, Norfolk Place, London W2 1PG, UK; s.johnston@imperial.ac.uk
Received 21 January 2013 - Accepted 1 February 2013 - Published Online First 22 February 2013
Abstract
During the 2009 H1N1 influenza pandemic, obesity was convincingly identified as a novel, independent risk factor for multiple markers of disease severity. Associations between numerous nosocomial and community-acquired clinical infections have previously been established; yet, little is known about the mechanisms underpinning the increased susceptibility to severe outcomes following pandemic H1N1/09 infection in obesity. Here, we present a brief synthesis of the recent advances in our understanding of the immunomodulatory effects of obesity on outcomes following respiratory viral infection, with a particular focus on pandemic influenza.
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<CITE></CITE>Chest clinic / Basic science for the chest physician
Obesity and susceptibility to severe outcomes following respiratory viral infection
Mark H Almond 1,2, Michael R Edwards 1, Wendy S Barclay 2, Sebastian L Johnston 1
Author Affiliations: <SUP>1</SUP>Airway Disease Infection Section, National Heart and Lung Institute, Imperial College London, UK <SUP>2</SUP>Department of Influenza, Imperial College London, London, UK
Correspondence to Professor Sebastian L Johnston, Airway Disease Infection Section, National Heart and Lung Institute, Imperial College London, Norfolk Place, London W2 1PG, UK; s.johnston@imperial.ac.uk
Received 21 January 2013 - Accepted 1 February 2013 - Published Online First 22 February 2013
Abstract
During the 2009 H1N1 influenza pandemic, obesity was convincingly identified as a novel, independent risk factor for multiple markers of disease severity. Associations between numerous nosocomial and community-acquired clinical infections have previously been established; yet, little is known about the mechanisms underpinning the increased susceptibility to severe outcomes following pandemic H1N1/09 infection in obesity. Here, we present a brief synthesis of the recent advances in our understanding of the immunomodulatory effects of obesity on outcomes following respiratory viral infection, with a particular focus on pandemic influenza.
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