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Einstein (Sao Paulo). 2012 Sep;10(3):306-311.
Pandemic influenza A/H1N1: comparative analysis of microscopic lung histopathological findings.
[Article in English, Portuguese]
Marchiori R, Bredt CS, Campos MM, Negretti F, Duarte PA.
Source
Hospital Universit?rio do Oeste do Paran?, Cascavel, PR, Brasil.
Abstract
OBJECTIVE:
To analyze the histopathological lung findings of four fatal cases of the 2009 H1N1 influenza pandemic and their correlation with clinical and epidemiological characteristics.
METHODS:
Descriptive data from medical records of four patients who died in the Intensive Care Unit of a university hospital in 2009. Nasopharyngeal aspirate specimens were collected from the patients and were analyzed by real-time polymerase chain reaction. Lung biopsy was performed post mortem; a score of intensity for pathological changes was applied.
RESULTS:
Three patients had positive real-time polymerase chain reaction (although all of them had a clinical diagnose of influenza H1N1). The main histopathological changes were: exudative diffuse alveolar damage with atelectasis; varying degrees of alveolar hemorrhage and edema, necrosis and sloughing of the respiratory epithelium in several bronchioli; and thrombus formation. One of the patients (the pregnant one) presented histopathological findings of cytomegalic inclusion.
CONCLUSION:
The pulmonary histopathological findings in patients with fatal 2009 H1N1 influenza pandemic disclosed intense alveolar damage and hemorrhage and severe bronchiolitis. A co-infection with cytomegalovirus was described in the pregnant patient.
PMID:
23386009
[PubMed - as supplied by publisher]
Free full text
Pandemic influenza A/H1N1: comparative analysis of microscopic lung histopathological findings.
[Article in English, Portuguese]
Marchiori R, Bredt CS, Campos MM, Negretti F, Duarte PA.
Source
Hospital Universit?rio do Oeste do Paran?, Cascavel, PR, Brasil.
Abstract
OBJECTIVE:
To analyze the histopathological lung findings of four fatal cases of the 2009 H1N1 influenza pandemic and their correlation with clinical and epidemiological characteristics.
METHODS:
Descriptive data from medical records of four patients who died in the Intensive Care Unit of a university hospital in 2009. Nasopharyngeal aspirate specimens were collected from the patients and were analyzed by real-time polymerase chain reaction. Lung biopsy was performed post mortem; a score of intensity for pathological changes was applied.
RESULTS:
Three patients had positive real-time polymerase chain reaction (although all of them had a clinical diagnose of influenza H1N1). The main histopathological changes were: exudative diffuse alveolar damage with atelectasis; varying degrees of alveolar hemorrhage and edema, necrosis and sloughing of the respiratory epithelium in several bronchioli; and thrombus formation. One of the patients (the pregnant one) presented histopathological findings of cytomegalic inclusion.
CONCLUSION:
The pulmonary histopathological findings in patients with fatal 2009 H1N1 influenza pandemic disclosed intense alveolar damage and hemorrhage and severe bronchiolitis. A co-infection with cytomegalovirus was described in the pregnant patient.
PMID:
23386009
[PubMed - as supplied by publisher]
Free full text
