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PLoS One. 2013;8(2):e54946. doi: 10.1371/journal.pone.0054946. Epub 2013 Feb 4.
Influenza A(H1N1)pdm09-Associated Pneumonia Deaths in Thailand.
Bunthi C, Thamthitiwat S, Baggett HC, Akarasewi P, Ruangchira-Urai R, Maloney SA, Ungchusak K.
Source
International Emerging Infections Program, Global Disease Detection Regional Center, Thailand Ministry of Public Health- US Centers for Disease Control and Prevention Collaboration, Nonthaburi, Thailand.
Abstract
BACKGROUND:
The first human infections with influenza A(H1N1)pdm09 virus were confirmed in April 2009. We describe the clinical and epidemiological characteristics of influenza A(H1N1)pdm09-associated pneumonia deaths in Thailand from May 2009-January 2010.
METHODS:
We identified influenza A(H1N1)pdm09-associated pneumonia deaths from a national influenza surveillance system and performed detailed reviews of a subset.
RESULTS:
Of 198 deaths reported, 49% were male and the median age was 37 years; 146 (73%) were 20-60 years. Among 90 deaths with records available for review, 46% had no identified risk factors for severe influenza. Eighty-eight patients (98%) received antiviral treatment, but only 16 (18%) initiated therapy within 48 hours of symptom onset.
CONCLUSIONS:
Most influenza A(H1N1)pdm09 pneumonia fatalities in Thailand occurred in adults aged 20-60 years. Nearly half lacked high-risk conditions. Antiviral treatment recommendations may be especially important early in a pandemic before vaccine is available. Treatment should be considered as soon as influenza is suspected.
PMID:
23390508
[PubMed - in process]
Free full text
Influenza A(H1N1)pdm09-Associated Pneumonia Deaths in Thailand.
Bunthi C, Thamthitiwat S, Baggett HC, Akarasewi P, Ruangchira-Urai R, Maloney SA, Ungchusak K.
Source
International Emerging Infections Program, Global Disease Detection Regional Center, Thailand Ministry of Public Health- US Centers for Disease Control and Prevention Collaboration, Nonthaburi, Thailand.
Abstract
BACKGROUND:
The first human infections with influenza A(H1N1)pdm09 virus were confirmed in April 2009. We describe the clinical and epidemiological characteristics of influenza A(H1N1)pdm09-associated pneumonia deaths in Thailand from May 2009-January 2010.
METHODS:
We identified influenza A(H1N1)pdm09-associated pneumonia deaths from a national influenza surveillance system and performed detailed reviews of a subset.
RESULTS:
Of 198 deaths reported, 49% were male and the median age was 37 years; 146 (73%) were 20-60 years. Among 90 deaths with records available for review, 46% had no identified risk factors for severe influenza. Eighty-eight patients (98%) received antiviral treatment, but only 16 (18%) initiated therapy within 48 hours of symptom onset.
CONCLUSIONS:
Most influenza A(H1N1)pdm09 pneumonia fatalities in Thailand occurred in adults aged 20-60 years. Nearly half lacked high-risk conditions. Antiviral treatment recommendations may be especially important early in a pandemic before vaccine is available. Treatment should be considered as soon as influenza is suspected.
PMID:
23390508
[PubMed - in process]
Free full text
