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Eur Respir J. 2012 Aug 16. [Epub ahead of print]
Differences between asthmatics and non-asthmatics hospitalised with influenza A infection.
Myles P, Nguyen-Van-Tam JS, Semple MG, Brett SJ, Bannister B, Read RC, Taylor BL, McMenamin J, Enstone JE, Nicholson KG, Openshaw P, Lim WS, Flu-Cin IC.
Source
University of Nottingham, Nottingham NG5 1PB.
Abstract
Asthmatics hospitalised because of influenza A infection are less likely to require intensive care or die compared to non-asthmatics. Reasons for this are unknown.A retrospective analysis of data on 1,520 patients admitted to 75 UK hospitals with confirmed influenza A/H1N1 2009 infection. A multivariable model was used to investigate reasons for the association between asthma and severe outcomes (intensive care unit support or death).Asthmatics were less likely than non-asthmatics to have severe outcome (11.2% vs 19.8%, unadjusted OR 0.51, 95%CI 0.36 to 0.72) despite a greater proportion requiring oxygen on admission (36.4% vs 26%, unadjOR 1.63) and similar rates of pneumonia (17.1% vs 16.6%, unadjOR 1.04). The results of multivariable logistic regression suggest the association of asthma with outcome (adjOR 0.62, 95%CI 0.36 to 1.05, p=0.075) is explained by pre-admission inhaled corticosteroid use (adjOR 0.34, 95%CI 0.18 to 0.66) and earlier admission (≤4 days from symptom onset) (adjOR 0.60, 95%CI 0.38 to 0.94). In asthmatics, systemic corticosteroids were associated with a decreased likelihood of severe outcomes (adjusted OR 0.36, 95% CI 0.18 to 0.72).Corticosteroid use and earlier hospital admission explained the association of asthma with less severe outcomes in hospitalised patients.
PMID:
22903963
[PubMed - as supplied by publisher]
Differences between asthmatics and non-asthmatics hospitalised with influenza A infection.
Myles P, Nguyen-Van-Tam JS, Semple MG, Brett SJ, Bannister B, Read RC, Taylor BL, McMenamin J, Enstone JE, Nicholson KG, Openshaw P, Lim WS, Flu-Cin IC.
Source
University of Nottingham, Nottingham NG5 1PB.
Abstract
Asthmatics hospitalised because of influenza A infection are less likely to require intensive care or die compared to non-asthmatics. Reasons for this are unknown.A retrospective analysis of data on 1,520 patients admitted to 75 UK hospitals with confirmed influenza A/H1N1 2009 infection. A multivariable model was used to investigate reasons for the association between asthma and severe outcomes (intensive care unit support or death).Asthmatics were less likely than non-asthmatics to have severe outcome (11.2% vs 19.8%, unadjusted OR 0.51, 95%CI 0.36 to 0.72) despite a greater proportion requiring oxygen on admission (36.4% vs 26%, unadjOR 1.63) and similar rates of pneumonia (17.1% vs 16.6%, unadjOR 1.04). The results of multivariable logistic regression suggest the association of asthma with outcome (adjOR 0.62, 95%CI 0.36 to 1.05, p=0.075) is explained by pre-admission inhaled corticosteroid use (adjOR 0.34, 95%CI 0.18 to 0.66) and earlier admission (≤4 days from symptom onset) (adjOR 0.60, 95%CI 0.38 to 0.94). In asthmatics, systemic corticosteroids were associated with a decreased likelihood of severe outcomes (adjusted OR 0.36, 95% CI 0.18 to 0.72).Corticosteroid use and earlier hospital admission explained the association of asthma with less severe outcomes in hospitalised patients.
PMID:
22903963
[PubMed - as supplied by publisher]
