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mBio. Epidemiology of the Influenza A Virus H5N1 Subtype and Memory of Immunity to the H2N2 Subtype

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  • mBio. Epidemiology of the Influenza A Virus H5N1 Subtype and Memory of Immunity to the H2N2 Subtype

    [Source: mBio, full text: (LINK). Extract, edited.]
    Epidemiology of the Influenza A Virus H5N1 Subtype and Memory of Immunity to the H2N2 Subtype


    Masanori Terajima, Jenny Aurielle B. Babon, and Francis A. Ennis

    Author Affiliations: Center for Infectious Disease and Vaccine Research - Division of Infectious Diseases and Immunology, Department of Medicine, University of Massachusetts Medical School, Worcester, Massachusetts, USA

    Address correspondence to Masanori Terajima, Masanori.Terajima@umassmed.edu.



    Letter to the Editor

    In their recent paper, Peter Palese and Taia T. Wang proposed a hypothesis to explain how an older circulating subtype of influenza A virus is replaced with a novel subtype (1). They and others also published experimental evidence supporting their hypothesis on the extinction of seasonal H1N1 viruses by the 2009 pandemic H1N1 viruses (2). Although they discussed only the disappearance of seasonal H1N1 and H2N2 subtypes, we think that the same mechanism may be working against the currently circulating H5N1 subtype.


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