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Acta Paediatr. 2011 Feb 1. doi: 10.1111/j.1651-2227.2011.02188.x. [Epub ahead of print]
Neurological Complications and Pandemic Influenza A (H1N1) Virus Infection.
Omari I, Breuer O, Kerem E, Berger I.
Department of Pediatrics, Hadassah-Hebrew University Medical Center, Mount Scopus Campus, Jerusalem, Israel Pediatric Neurology Unit, Department of Pediatrics, Hadassah-Hebrew University Medical Center, Mount Scopus Campus, Jerusalem, Israel.
Abstract
Aim: To report on a different clinical course of pandemic influenza A (H1N1) infection among children who were neurologically impaired before the acute onset of the disease, in comparison with children who were neurologically intact. Methods: In a period of 6 months six children with neurological complications associated with pandemic A (H1N1) infection identified in a single institution pediatric emergency room. The children suffered from seizures or altered mental status during pandemic A (H1N1) infection. All children underwent extensive clinical and laboratory assessment. Three children were neurologically impaired before the acute onset of the H1N1 infection. The other three were neurologically intact before the acute viral infection. Results: In all 6 patients, pandemic influenza A (H1N1) viral RNA was detected in nasopharyngeal specimens but none in the cerebrospinal fluid. Five children fully recovered or returned to baseline at discharge. The clinical course of the disease and recovery were different between the children who were neurologically impaired before the acute viral infection and those who were neurologically intact. Conclusions: It is possible that children with various neurological conditions are in a higher risk to develop further neurological complications during pandemic Influenza A (H1N1) infection.
Copyright ? 2011 Foundation Acta Paediatrica.
PMID: 21284719 [PubMed - as supplied by publisher]
Neurological Complications and Pandemic Influenza A (H1N1) Virus Infection.
Omari I, Breuer O, Kerem E, Berger I.
Department of Pediatrics, Hadassah-Hebrew University Medical Center, Mount Scopus Campus, Jerusalem, Israel Pediatric Neurology Unit, Department of Pediatrics, Hadassah-Hebrew University Medical Center, Mount Scopus Campus, Jerusalem, Israel.
Abstract
Aim: To report on a different clinical course of pandemic influenza A (H1N1) infection among children who were neurologically impaired before the acute onset of the disease, in comparison with children who were neurologically intact. Methods: In a period of 6 months six children with neurological complications associated with pandemic A (H1N1) infection identified in a single institution pediatric emergency room. The children suffered from seizures or altered mental status during pandemic A (H1N1) infection. All children underwent extensive clinical and laboratory assessment. Three children were neurologically impaired before the acute onset of the H1N1 infection. The other three were neurologically intact before the acute viral infection. Results: In all 6 patients, pandemic influenza A (H1N1) viral RNA was detected in nasopharyngeal specimens but none in the cerebrospinal fluid. Five children fully recovered or returned to baseline at discharge. The clinical course of the disease and recovery were different between the children who were neurologically impaired before the acute viral infection and those who were neurologically intact. Conclusions: It is possible that children with various neurological conditions are in a higher risk to develop further neurological complications during pandemic Influenza A (H1N1) infection.
Copyright ? 2011 Foundation Acta Paediatrica.
PMID: 21284719 [PubMed - as supplied by publisher]
