Arch Virol . Protective effects of SP600125 on mice infected with H1N1 influenza A virus

[tetano]

Arch Virol


. 2021 May 20.
doi: 10.1007/s00705-021-05103-0. Online ahead of print.
Protective effects of SP600125 on mice infected with H1N1 influenza A virus


Yuling Tang ¹ , Guanghui Yang ¹ , Yuxiang Li ¹ , Ming Wang ¹ , Gebin Li ² , Yanxin Hu ³



Affiliations

• PMID: 34014386
• DOI: 10.1007/s00705-021-05103-0

Abstract

Influenza A virus (IAV) can cause high morbidity and mortality globally every year. Myriad host kinases and their related signaling pathways are involved in IAV infection, and the important role of the c-Jun N-terminal kinase signaling pathway during infection has been demonstrated. SP600125, an inhibitor of c-Jun N-terminal kinase, was found in our previous study to suppress IAV replication in vitro. In this study, we established a mouse model of H1N1 IAV infection and treated the mice with SP600125 to study its protective effect. The results showed that SP600125 treatment reduced the pulmonary inflammatory response, lung injury, and pulmonary viral load and increased the survival rate of H1N1-infected mice. Our data confirm the crucial role of c-Jun N terminal kinase in H1N1 virus replication and inflammatory responses in vivo. Hence, we speculate that SP600125 has a potential antiviral therapeutic benefit against IAV infection.