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Effectiveness of favipiravir (T-705) against wild-type and oseltamivir-resistant influenza B virus in mice

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  • Effectiveness of favipiravir (T-705) against wild-type and oseltamivir-resistant influenza B virus in mice


    Virology. 2020 Feb 24;545:1-9. doi: 10.1016/j.virol.2020.02.005. [Epub ahead of print]



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    Abstract

    The emergence of resistant mutants to the wildly used neuraminidase inhibitors (NAIs) makes the development of novel drugs necessary. Favipiravir (T-705) is one of the RNA-dependent RNA polymerase (RdRp) inhibitors developed in recent years. To examine the efficacy of T-705 against influenza B virus infections in vivo, C57BL/6 mice infected with wild-type or oseltamivir-resistant influenza B/Memphis/20/96 viruses were treated with T-705. Starting 2 h post inoculation (hpi), T-705 was orally administered to mice BID at dosages of 50, 150, or 300 mg/kg/day for 5 days. Oseltamivir was used as control. Here, we showed that T-705 protected mice from lethal infection in a dose-dependent manner. T-705 administration also significantly reduced viral loads and suppressed pulmonary pathology. In addition, phenotypic assays demonstrated that no T-705-resistant viruses emerged after T-705 treatment. In conclusion, T-705 can be effective to protect mice from lethal infection with both wild-type and oseltamivir-resistant influenza B viruses.
    Copyright ? 2020 Elsevier Inc. All rights reserved.



    KEYWORDS:

    Favipiravir; Influenza B virus; Oseltamivir; Oseltamivir-resistant virus


    PMID:32174453DOI:10.1016/j.virol.2020.02.005

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