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Detection and Characterization of Influenza B Virus With Reduced Neuraminidase Susceptibility in a Stem Cell Transplant Recipient

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    Detection and Characterization of Influenza B Virus With Reduced Neuraminidase Susceptibility in a Stem Cell Transplant Recipient


    Open Forum Infect Dis. 2019 Nov 18;6(12):ofz493. doi: 10.1093/ofid/ofz493. eCollection 2019 Dec. Detection and Characterization of Influenza B Virus With Reduced Neuraminidase Susceptibility in a Stem Cell Transplant Recipient.

    Kodiyanplakkal RPL1, Laplante JM2, Westblade LF1,3, van Besien K4, Salvatore M5, St George K2.
    Author information

    Abstract

    Antiviral-resistant influenza viruses in the clinical environment, especially type B, are reported rarely. A stem cell transplant recipient remained influenza B positive for 2 months, despite repeated antiviral treatments. Laboratory tests demonstrated the evolution and persistence of neuraminidase inhibitor-resistant influenza B virus with a substitution at codon 119.
    ? The Author(s) 2019. Published by Oxford University Press on behalf of Infectious Diseases Society of America.


    KEYWORDS:

    antiviral resistance; influenza B virus; neuraminidase inhibitors; neuraminidase mutation; stem cell transplant

    PMID: 32128335 PMCID: PMC7047943 DOI: 10.1093/ofid/ofz493
    Free PMC Article

    Tags: None
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