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Emerg Infect Dis. 2019 Oct 17;25(10). doi: 10.3201/eid2510.190607. [Epub ahead of print]
Susceptibility of Influenza A, B, C, and D Viruses to Baloxavir1.
Mishin VP, Patel MC, Chesnokov A, De La Cruz J, Nguyen HT, Lollis L, Hodges E, Jang Y, Barnes J, Uyeki T, Davis CT, Wentworth DE, Gubareva LV.
Abstract
Baloxavir showed broad-spectrum in vitro replication inhibition of 4 types of influenza viruses (90% effective concentration range 1.2-98.3 nmol/L); susceptibility pattern was influenza A ˃ B ˃ C ˃ D. This drug also inhibited influenza A viruses of avian and swine origin, including viruses that have pandemic potential and those resistant to neuraminidase inhibitors.
KEYWORDS:
H7N9; United States; avian influenza; baloxavir; baloxavir marboxil; drug susceptibility; highly pathogenic viruses; influenza viruses; pandemic potential; respiratory infections; viruses; zoonoses; zoonotic influenza
PMID: 31287050 DOI: 10.3201/eid2510.190607
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Susceptibility of Influenza A, B, C, and D Viruses to Baloxavir1.
Mishin VP, Patel MC, Chesnokov A, De La Cruz J, Nguyen HT, Lollis L, Hodges E, Jang Y, Barnes J, Uyeki T, Davis CT, Wentworth DE, Gubareva LV.
Abstract
Baloxavir showed broad-spectrum in vitro replication inhibition of 4 types of influenza viruses (90% effective concentration range 1.2-98.3 nmol/L); susceptibility pattern was influenza A ˃ B ˃ C ˃ D. This drug also inhibited influenza A viruses of avian and swine origin, including viruses that have pandemic potential and those resistant to neuraminidase inhibitors.
KEYWORDS:
H7N9; United States; avian influenza; baloxavir; baloxavir marboxil; drug susceptibility; highly pathogenic viruses; influenza viruses; pandemic potential; respiratory infections; viruses; zoonoses; zoonotic influenza
PMID: 31287050 DOI: 10.3201/eid2510.190607
Free full text