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Heliyon. 2019 Jun 17;5(6):e01941. doi: 10.1016/j.heliyon.2019.e01941. eCollection 2019 Jun.
Physico-chemical studies on binary aqueous solutions of Anti-Viral Influenza drugs.
Punitha S1, Uvarani R2, Panneerselvam A3, Nithiyanantham S4.
Author information
Abstract
The ultrasonic velocity, density, viscosity and absorption have been measured for solution of Influenza Anti-Viral drugs (Amantadine and Oseltamivir) are presented at room temperature 303K. By taking measurements of Anti Influenza Viral drugs at 0.2, 0.4 and 0.6% concentrations of each solution. The aim of the study is to increase the solubility, stability, sweetness of drugs by the formation of complexation. The ultrasonic velocity, density and viscosity have been measured at 2MHz for the aqueous solutions of (i) Influenza Anti-Viral Drugs + HPMC (Hydroxy Propyl Methyl Cellulose), Lactose and CaCl2 (Calcium Chloride at different concentrations at a temperature 303K.The acoustical parameters such as adiabatic compressibility (β), intermolecular free length (Lf), internal pressure (πi), Rao's constant (R), relaxation time (τ), acoustical impedance (Za), absorption coefficient (α/f2), free volume (Vf), cohesive energy and solvation number (Sn) have been computed. These properties are attributed to solute-solvent interactions through hydrogen bonding, segment-segment interaction, molecular association, polymer-solvent interaction, polymer-polymer interaction and etc. The total absorption can be considered as the sum of contributions from solute-solvent interactions. These results are further supported by FTIR studies.
KEYWORDS:
Calcium chloride; Derived parameter; HPMC; Lactose; Pharmaceutical chemistry influenza anti-viral drugs; Pharmaceutical science; Physical chemistry
PMID: 31249897 PMCID: PMC6584764 DOI: 10.1016/j.heliyon.2019.e01941
Free PMC Article
Physico-chemical studies on binary aqueous solutions of Anti-Viral Influenza drugs.
Punitha S1, Uvarani R2, Panneerselvam A3, Nithiyanantham S4.
Author information
Abstract
The ultrasonic velocity, density, viscosity and absorption have been measured for solution of Influenza Anti-Viral drugs (Amantadine and Oseltamivir) are presented at room temperature 303K. By taking measurements of Anti Influenza Viral drugs at 0.2, 0.4 and 0.6% concentrations of each solution. The aim of the study is to increase the solubility, stability, sweetness of drugs by the formation of complexation. The ultrasonic velocity, density and viscosity have been measured at 2MHz for the aqueous solutions of (i) Influenza Anti-Viral Drugs + HPMC (Hydroxy Propyl Methyl Cellulose), Lactose and CaCl2 (Calcium Chloride at different concentrations at a temperature 303K.The acoustical parameters such as adiabatic compressibility (β), intermolecular free length (Lf), internal pressure (πi), Rao's constant (R), relaxation time (τ), acoustical impedance (Za), absorption coefficient (α/f2), free volume (Vf), cohesive energy and solvation number (Sn) have been computed. These properties are attributed to solute-solvent interactions through hydrogen bonding, segment-segment interaction, molecular association, polymer-solvent interaction, polymer-polymer interaction and etc. The total absorption can be considered as the sum of contributions from solute-solvent interactions. These results are further supported by FTIR studies.
KEYWORDS:
Calcium chloride; Derived parameter; HPMC; Lactose; Pharmaceutical chemistry influenza anti-viral drugs; Pharmaceutical science; Physical chemistry
PMID: 31249897 PMCID: PMC6584764 DOI: 10.1016/j.heliyon.2019.e01941
Free PMC Article