Antiviral treatment and virological monitoring of oseltamivir-resistant influenza virus A(H1N1)pdm09 in a patient with chronic B lymphocytic leukemia

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J Infect Chemother. 2019 Apr 20. pii: S1341-321X(18)30460-4. doi: 10.1016/j.jiac.2018.11.008. [Epub ahead of print]
Antiviral treatment and virological monitoring of oseltamivir-resistant influenza virus A(H1N1)pdm09 in a patient with chronic B lymphocytic leukemia.

Salata C¹, Sgarabotto D², Del Vecchio C¹, Solimbergo E³, Marini G², Nicol? S², Franchin E¹, Parolin C¹, Calistri A³, Pal? G⁴.
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Abstract

We report the virological monitoring and the antiviral therapy adopted for the treatment of a patient affected by chronic B lymphocytic leukemia, who experienced a severe pneumonia with long-term shedding of influenza virus A(H1N1)pdm09, characterized by an early development of oseltamivir resistance.
Copyright ? 2018 Japanese Society of Chemotherapy and The Japanese Association for Infectious Diseases. Published by Elsevier Ltd. All rights reserved.


KEYWORDS:

A(H1N1)pdm09; Chronic lymphocytic leukemia; Influenza virus; Oseltamivir resistance; Triple-combination antiviral drug therapy (TCAD); Zanamivir

PMID: 31014561 DOI: 10.1016/j.jiac.2018.11.008

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