Eurosurv. Assessing baloxavir susceptibility of influenza viruses circulating in the United States during the 2016/17 and 2017/18 seasons

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Assessing baloxavir susceptibility of influenza viruses circulating in the United States during the 2016/17 and 2017/18 seasons

• Larisa V Gubareva¹, Vasiliy P Mishin¹, Mira C Patel^1,2, Anton Chesnokov¹, Ha T Nguyen^1,2, Juan De La Cruz^1,2, Sarah Spencer¹, Angela P Campbell¹, Mallory Sinner³, Heather Reid³, Rebecca Garten¹, Jackie M Katz¹, Alicia M Fry¹, John Barnes¹, David E Wentworth¹

The anti-influenza therapeutic baloxavir targets cap-dependent endonuclease activity of polymerase acidic (PA) protein. We monitored baloxavir susceptibility in the United States with next generation sequencing analysis supplemented by phenotypic one-cycle infection assay. Analysis of PA sequences of 6,891 influenza A and B viruses collected during 2016/17 and 2017/18 seasons showed amino acid substitutions: I38L (two A(H1N1)pdm09 viruses), E23G (two A(H1N1)pdm09 viruses) and I38M (one A(H3N2) virus); conferring 4?10-fold reduced susceptibility to baloxavir.

full article

https://www.eurosurveillance.org/content/10.2807/1560-7917.ES.2019.24.3.1800666#abstract_content