Tweet
J Asian Nat Prod Res. 2018 Nov 10:1-10. doi: 10.1080/10286020.2018.1520221. [Epub ahead of print]
Santin inhibits influenza A virus replication through regulating MAPKs and NF-κB pathways.
Zhong M1,2,3, Wang HQ2, Yan HY2, Wu S2, Gu ZY3, Li YH2.
Author information
Abstract
Influenza A virus (IAV) causes high morbidity and significant mortality worldwide. Given the limitations of existing vaccination and antiviral drugs, it is urgent to develop new anti-influenza drugs. Flavonoids are natural polyphenolic compounds with broad applications to treatments for influenza infection. In this study, we demonstrated that santin, a flavonoid compound, showed anti-influenza activity in MDCK and THP-1 cells. Mechanistic studies revealed that santin depressed the phosphorylation of p38 MAPK, JNK/SAPK, ERK, and NF-κB factor and subsequently attenuated the expression of inflammatory cytokines in IAV-infected cells. Thus, santin is a potential candidate for the future development of anti-IAV drugs. [Formula: see text].
KEYWORDS:
MAPKs; NF-κB; Santin; inflammatory cytokines; influenza A virus
PMID: 30417663 DOI: 10.1080/10286020.2018.1520221
Santin inhibits influenza A virus replication through regulating MAPKs and NF-κB pathways.
Zhong M1,2,3, Wang HQ2, Yan HY2, Wu S2, Gu ZY3, Li YH2.
Author information
Abstract
Influenza A virus (IAV) causes high morbidity and significant mortality worldwide. Given the limitations of existing vaccination and antiviral drugs, it is urgent to develop new anti-influenza drugs. Flavonoids are natural polyphenolic compounds with broad applications to treatments for influenza infection. In this study, we demonstrated that santin, a flavonoid compound, showed anti-influenza activity in MDCK and THP-1 cells. Mechanistic studies revealed that santin depressed the phosphorylation of p38 MAPK, JNK/SAPK, ERK, and NF-κB factor and subsequently attenuated the expression of inflammatory cytokines in IAV-infected cells. Thus, santin is a potential candidate for the future development of anti-IAV drugs. [Formula: see text].
KEYWORDS:
MAPKs; NF-κB; Santin; inflammatory cytokines; influenza A virus
PMID: 30417663 DOI: 10.1080/10286020.2018.1520221