Tweet
Acta Virol. 2018;62(2):191-195. doi: 10.4149/av_2018_211.
Antiviral effect of a derivative of isonicotinic acid enisamium iodide (FAV00A) against influenza virus.
Cocking D, Cinatl J, Boltz DA, Peng X, Johnson W, Muzzio M, Syarkevych O, Kostyuk G, Goy A, Mueller L, Margitich VI.
Abstract
With only a single class of antiviral drugs existing for treatment of influenza (neuraminidase inhibitors), the search for novel effective compounds is urgently needed. We evaluated a low molecular mass compound, enisamium iodide (FAV00A), against influenza virus infections in primary differentiated normal human bronchial epithelial (NHBE) cells, and in ferrets. FAV00A (500 ?g/ml) markedly inhibited influenza virus replication and reduced viral M-gene expression in NHBE cells. Treatment of ferrets with FAV00A (200 mg/kg once daily for 7 days) initiated 24 h after inoculation with 105 TCID50 of influenza A/Wisconsin/67/2005 (H3N2) virus resulted in a significant decrease in virus titers in the upper respiratory tract. Our data show that FAV00A exhibits an antiviral effect against influenza virus in NHBE cells and provides some benefits in a ferret model. Thus, further Keywords: antiviral agents; enisamium iodide; influenza virus; MDCK cells; NHBE cells; ferrets.
PMID: 29895160 DOI: 10.4149/av_2018_211
Antiviral effect of a derivative of isonicotinic acid enisamium iodide (FAV00A) against influenza virus.
Cocking D, Cinatl J, Boltz DA, Peng X, Johnson W, Muzzio M, Syarkevych O, Kostyuk G, Goy A, Mueller L, Margitich VI.
Abstract
With only a single class of antiviral drugs existing for treatment of influenza (neuraminidase inhibitors), the search for novel effective compounds is urgently needed. We evaluated a low molecular mass compound, enisamium iodide (FAV00A), against influenza virus infections in primary differentiated normal human bronchial epithelial (NHBE) cells, and in ferrets. FAV00A (500 ?g/ml) markedly inhibited influenza virus replication and reduced viral M-gene expression in NHBE cells. Treatment of ferrets with FAV00A (200 mg/kg once daily for 7 days) initiated 24 h after inoculation with 105 TCID50 of influenza A/Wisconsin/67/2005 (H3N2) virus resulted in a significant decrease in virus titers in the upper respiratory tract. Our data show that FAV00A exhibits an antiviral effect against influenza virus in NHBE cells and provides some benefits in a ferret model. Thus, further Keywords: antiviral agents; enisamium iodide; influenza virus; MDCK cells; NHBE cells; ferrets.
PMID: 29895160 DOI: 10.4149/av_2018_211