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Synthesis of S-linked NeuAc-α(2-6)-di-LacNAc bearing liposomes for H1N1 influenza virus inhibition assays

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  • Synthesis of S-linked NeuAc-α(2-6)-di-LacNAc bearing liposomes for H1N1 influenza virus inhibition assays

    Bioorg Med Chem. 2018 Feb 12. pii: S0968-0896(17)32416-1. doi: 10.1016/j.bmc.2018.02.012. [Epub ahead of print]
    Synthesis of S-linked NeuAc-α(2-6)-di-LacNAc bearing liposomes for H1N1 influenza virus inhibition assays.

    Cheng HW1, Wang HW1, Wong TY1, Yeh HW1, Chen YC1, Liu DZ2, Liang PH3.
    Author information

    Abstract

    S-NeuAc-α(2-6)-di-LacNAc (5) was efficiently synthesized by a [2+2] followed by a [1+4] glycosylation, and later conjugated with 1,2-dilauroyl-sn-glycero-3-phosphoethanolamine (DLPE) to form both single-layer and multi-layer homogeneous liposomes in the presence of dipalmitoyl phosphatidylcholine (DPPC) and cholesterol. These liposomes were found to be weak inhibitors in both the influenza virus entry assay and the hemagglutination inhibition assay. The single layer liposome was found to more efficiently interfere with the entry of the H1N1 influenza virus into MDCK cells than the multilayer liposome containing 5.


    KEYWORDS:

    Hemagglutinin; Influenza; Liposome; Sialic acid

    PMID: 29472127 DOI: 10.1016/j.bmc.2018.02.012
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